摘要
传统的抗生素治疗方案易引发耐药菌的产生,还可能诱发过敏等不良反应,限制了其临床使用。光动力疗法(PDT)作为一种新型的抗菌策略,具有微创性、组织选择性及耐药菌生成的风险最小等特性,在临床治疗中展现出广阔的应用前景。本研究对天然光敏剂2,2':5',2''-噻吩-5-甲醛进行分子修饰,成功合成了具有聚集感应发光(AIE)特性的光敏剂TPA-TSF-CHO。经分子修饰后,该化合物的吸收光谱红移,由此克服了原始分子的局限性,表现出更低的能隙值和更高的单线态氧生成效率。在氙灯光源的激发下,该光敏剂对金黄色葡萄球菌和铜绿假单胞菌具有99.9%的灭杀率。
Conventional antibiotic therapies not only facilitate the emergence of drug-resistant bacteria but may also induce adverse reactions such as allergic responses,thereby limiting their clinical applications.Photodynamic therapy(PDT),as a novel antibacterial strategy,has demonstrated substantial clinical potential due to its minimally invasive nature,tissue selectivity,and minimal risk of inducing drug resistance.In this study,we performed molecular modification on the natural photosensitizer 2,2':5',2''-thiophene-5-carbaldehyde to successfully synthesize a photosensitizer TPA-TSF-CHO,which exhibits aggregation-induced emission(AIE)properties.Through molecular modification,this compound overcame the limitations of the original molecule by achieving a redshift in its absorption spectrum,thereby exhibiting a lower bandgap and higher singlet oxygen generation efficiency.Under xenon lamp irradiation,this photosensitizer achieved a 99.9%eradication rate against both Staphylococcus aureus and Pseudomonas aeruginosa.
作者
朱麟辰
刘海波
ZHU Linchen;LIU Haibo(School of Chemistry and Chemical Engineering,Guangxi University,Nanning 530004,China)
出处
《化工技术与开发》
2025年第10期5-11,共7页
Technology & Development of Chemical Industry
基金
国家自然科学基金项目(22167003)。
关键词
有机光敏剂
聚集感应发光
光动力抗菌
organic photosensitizer
aggregation-induced emission
photodynamic antibacterial
