摘要
目的:以右心衰患者作为观察对象,以伊伐布雷定早期干预作为治疗方法,就观察对象采用上述治疗方法的临床效果进行分析和探讨。方法:研究以2022年7月—2023年12月广东医科大学附属医院接收的100例右心衰竭病例为样本,依据入院时间将样本等分为两个组别。其中,2022年7月—2023年3月入院的病例设定为对照组,共包含50例,实施左西孟旦治疗方案;2023年4—12月入院的病例则作为观察组,同样包含50例,在对照组的基础上联合伊伐布雷定早期干预。对比两组的临床疗效、治疗前后的心功能指标及不良反应发生率。结果:于临床总有效率对比层面,相较于对照组,观察组呈现出的有效率数值更高,差异有统计学意义(P<0.05);治疗后,在左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)的比较上,与对照组相比,观察组相对较低,且在左室射血分数(LVEF)的比较上,与对照组相比,观察组相对较高,差异有统计学意义(P<0.05);就不良反应发生率的对比情况而言,对照组同观察组相较,差异无统计学意义(P>0.05)。结论:针对右心衰病症,于早期阶段运用伊伐布雷定实施干预措施,能够取得颇为理想的治疗效果,有利于改善其心功能指标,且安全性良好。
Objective:Taking patients with right heart failure as the observation subjects and early intervention with ivabradine as the treatment method,the clinical effects of the above treatment methods on the observation subjects were analyzed and discussed.Method:The study took 100 cases of right heart failure received by the Affiliated Hospital of Guangdong Medical University from July 2022 to December 2023 as samples and divided the samples into two equal groups based on the time of admission.Among them,the cases admitted to the hospital from July 2022 to March 2023 were set as the control group,including a total of 50 cases,and were treated with levosimendan.Cases admitted to the hospital from April to December 2023 were regarded as the observation group,which also included 50 cases.On the basis of the control group,early intervention with ivabradine was combined.The clinical efficacy,cardiac function indicators before and after treatment,and the incidence of adverse reactions of the two groups were compared.Result:In terms of the comparison of the total clinical effective rate,compared with the control group,the observation group showed a higher effective rate value,and the difference was statistically significant(P<0.05).After treatment,in the comparison of left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVEDD),the observation group was relatively lower compared with the control group.Moreover,in the comparison of left ventricular ejection fraction(LVEF),the observation group was relatively higher compared with the control group,and the differences were statistically significant(P<0.05).In terms of the comparison of the total clinical effective rate,compared with the control group,the observation group showed a higher effective rate value,and the difference was statistically significant(P>0.05).Conclusion:For right heart failure,the application of ivabradine intervention measures in the early stage can achieve quite ideal therapeutic effects,which is conducive to improving cardiac function indicators and has good safety.
作者
黄菲
谢晓明
郑重洲
陈春梅
HUANG Fei;XIE Xiaoming;ZHENG Chongzhou;CHEN Chunmei(Affiliated Hospital of Guangdong Medical University,Zhanjiang 524002,China;不详)
出处
《中外医学研究》
2025年第26期40-43,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
2022年湛江市非资助科技攻关计划项目(2022B01208)。
关键词
右心衰
伊伐布雷定
左西孟旦
心功能
Right heart failure
Ivabradine
Left West Mengdan
Cardiac function
