摘要
目的:探讨抗菌药物使用强度与医院感染微生物检出率及耐药趋势之间的关联性,为合理使用抗菌药物、控制医院感染提供依据。方法:收集2023年3月—2025年3月南阳张仲景医院800例住院患者的抗菌药物使用数据、医院感染微生物检出情况及耐药数据,计算抗菌药物使用强度(DDDs),分析其与微生物检出率及耐药率的相关性。结果:2023年3月—2025年3月,我院住院患者抗菌药物使用强度、微生物总检出率、耐药菌总检出率、MRSA检出率、CRAB检出率、CRPA检出率均呈逐年下降趋势。800例患者中共检出病原菌280株,其中革兰氏阴性菌160株、革兰氏阳性菌90株、真菌30株。抗菌药物使用强度与医院感染微生物的总检出率呈正相关(r=0.651,P<0.05),与革兰氏阴性菌的检出率相关性尤为显著(r=0.723,P<0.05),与耐药菌的检出率也存在显著相关性(r=0.783,P<<0.05),对MRSA(r=0.685,P<0.05)、CRAB(r=0.756,P<0.05)和CRPA(r=0.701,P<0.05)重症监护病房(ICU)的抗菌药物使用强度最高(50.2 DDDs),微生物检出率(45.00%)和耐药率(25.00%)最高。呼吸内科和外科的抗菌药物使用强度分别为48.5DDDs和47 DDDs,微生物检出率和耐药率相对较高。结论:抗菌药物使用强度对医院感染微生物检出率及耐药趋势有重要影响,需加强抗菌药物管理,优化使用策略,以降低医院感染风险和耐药菌的传播。
Objective:To explore the correlation between the use intensity of antibiotics and the detection rate and drug resistance trend of microorganisms in hospital infection,and to provide evidence for rational use of antibiotics and control of hospital infection,Methods:The data of antimicrobial use,microbial detection and drug resistance of 800 inpatients in Nanyang Zhangzhongjing Hospital from March 2023 to March 2025 were collected.The intensity of antimicrobial use(DDDs)was calculated,and its correlation with microbial detection rate and drug resistance rate was analyzed.Results:From March 2023 to March 2025,the use intensity of antibiotics,the total detection rate of microorganisms,the total detection rate of drug-resistant bacteria,the detection rate of MRSA,the detection rate of CRAB and the detection rate of CRPA in hospitalized patients in our hospital showed a downward trend year by year.A total of 280 strains of pathogenic bacteria were detected in 800 patients,including 160 strains of Gram-negative bacteria,90 strains of Gram-positive bacteria and 30 strains of fungi.The use intensity of antibiotics was positively correlated with the total detection rate of microorganisms in nosocomial infection(r=0.651,P<0.05),especially with the detection rate of Gram-negative bacteria(r=0.723,P<0.05),and with the detection rate of drug-resistant bacteria(r=0.783,P<0.05).For MRSA(r=0.685,P<0.05),CRAB(r=0.756,P<0.05)and CRPA(r=0.701,P<0.05),the intensive care unit(ICU)had the highest antibacterial drug use intensity(50.2 DDDs),the highest microbial detection rate(45.00%)and drug resistance rate(25.00%).The DDDs of antibiotics in respiratory medicine and surgery were 48.5 DDDs and 47 DDDs,respectively.The detection rate and drug resistance rate of microorganisms were relatively high.Conclusion:The use intensity of antibiotics has an important impact on the detection rate and drug resistance trend of nosocomial infection microorganisms.It is necessary to strengthen the management of antibiotics and optimize the use strategy to reduce the risk of nosocomial infection and the spread of drugresistantbacteria.
作者
张庆荣
李小毓
ZHANG Qingrong;LI Xiaoyu(Department of Laboratory Medicine,Zhang Zhongjing Hospital,Nanyang,Henan 473000,China)
出处
《中国药物滥用防治杂志》
2025年第9期1608-1610,1614,共4页
Chinese Journal of Drug Abuse Prevention and Treatment
基金
河南省医学科技攻关计划项目(编号:LHGJ20191468)。
关键词
抗菌药物使用强度
医院感染
微生物检出率
耐药趋势
关联性分析
Antibacterial drug use intensity
Hospital infection
Microbial detection rate
Drug resistance trend
Correlation analysis
