摘要
目的:探究养心汤联合美托洛尔对室性心律失常患者N末端B型利钠肽原(NT-proBNP)、心率变异性及临床疗效的影响。方法:将80例室性心律失常患者按随机数字表法分为对照组和研究组各40例。对照组口服美托洛尔治疗,研究组在对照组的基础上联合口服养心汤,两组均持续治疗3个月。记录两组患者治疗后的临床总有效率及不良反应发生情况;于治疗前后评估患者中医证候评分,检测患者血清中超敏C反应蛋白(hs-CRP)、NT-proBNP、脂联素(APN)水平变化。24 h连续动态心电图记录仪记录全部窦性心搏标准差(SDNN)、窦性心搏均值标准差(SDANN)、相邻正常心动周期差值超过50 ms心跳次数比例(pNN50)。结果:研究组患者临床总有效率(75.00%)高于对照组(52.50%)(P<0.05)。治疗后,两组患者中医证候评分、hs-CRP、NT-proBNP水平降低,APN、SDNN、SDANN、pNN50升高,组间比较,差异均具有统计学意义(P<0.05)。两组患者不良反应比较差异无统计学意义(P>0.05)。结论:养心汤联合美托洛尔可有效降低室性心律失常患者血清中NT-proBNP,显著提升其临床效果。
Objective:To explore the effect of Yangxin Decoction(养心汤)combined with metoprolol on N-terminal B-type natriuretic peptide(NT-proBNP),heart rate variability and efficacy in patients with ventricular arrhythmia.Methods:Eighty patients with ventricular arrhythmia were randomly divided into control group and research group,40 patients in each group.The control group was treated with oral administration of metoprolol,and the research group was further treated with oral administration of Yangxin Decoction.Both groups were treated for 3 months.The total clinical effective rate and adverse reactions of the two groups after treatment were recorded.The traditional Chinese medicine(TCM)syndrome scores,the levels of serum high-sensitivity C-reactive protein(hs-CRP),NT-proBNP and adiponectin(APN)were detected before and after treatment.The standard deviation of all sinus beats(SDNN),standard deviation of mean sinus beats(SDANN),and the percentage of successive normal cardiac interbeat intervals greater than 50 msec(pNN50)were recorded by 24-hr continuous dynamic electrocardiogram recorder.Results:The total effective rate of the research group(75.00%)was higher than that of the control group(52.50%)(P<0.05).After the treatment,in both groups the TCM syndrome scores,hs-CRP and NT-proBNP levels decreased,APN,SDNN,SDANN and pNN50 increased(P<0.05).There was no statistically significance in adverse reactions between the two groups of patients.Conclusion:Yangxin Decoction combined with metoprolol can effectively reduce NT-ProBNP in serum of patients with ventricular arrhythmia with improved efficacy.
作者
翟文姬
邓立梅
代洪绪
ZHAI Wenji;DENG Limei;DAI Hongxu(The Second Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150001,China;Heilongjiang Academy of Chinese Medicine Sciences,Harbin 150036,China)
出处
《山东中医杂志》
2025年第10期1121-1126,共6页
Shandong Journal of Traditional Chinese Medicine
基金
黑龙江省中医药科研项目(编号:ZHY2023-069)。
关键词
养心汤
美托洛尔
室性心律失常
N末端B型利钠肽原
Yangxin Decoction
metoprolol
ventricular arrhythmia
N-terminal B-type natriuretic peptide
