摘要
创伤性脑损伤(traumatic brain injury,TBI)是发病率、患病率最高的神经系统疾病,为全社会带来了巨大的公共卫生负担。深入研究TBI的生物力学原理有助于提升头部防护效果,发展快速评估技术并采取及时干预,从而降低伤情恶化的风险。人类头部有限元模型(finite element head model,FEHM)作为一种数值分析工具,能够模拟头部在受到冲击时的动态响应,包括脑组织的应力应变时空分布、颅内压的变化等,为理解创伤性脑损伤的力学机制提供了重要依据。本文详细总结了国内外主流的人类头部有限元模型的现状与发展,追溯了模型的发展历程,总结了模型的特点并介绍了基于有限元模型的TBI机制研究进展。对相关研究的总结和梳理将有助于开发新型FEHM,并为创伤性脑损伤的风险评估及防护装备的设计提供理论指导和技术支撑。
Traumatic brain injury(TBI)is the neurological disorder with the highest incidence and prevalence,and poses a huge public health burden for the whole society.An in-depth study of the biomechanics of TBI can help to improve the effectiveness of head protection,develop rapid assessment techniques and take timely interventions,thus reducing the risk of injury deterioration.As a numerical analysis tool,the finite element head model(FEHM)is able to simulate the dynamic response of the head during impact,including the spatial and temporal distribution of stress-strain in brain tissues,and the change of intracranial pressure,which provides an important basis for understanding the mechanical mechanism of TBI.This paper summarizes in detail the current status and development of mainstream finite element models of the human head at home and abroad,traces the development of the models,summarises the characteristics of the models and introduces the research progress of TBI mechanisms based on finite element models.The summary and sorting out of related research will be helpful for the development of new FEHMs and provide theoretical guidance and technical support for the risk assessment of traumatic brain injury and the design of protective equipment.
作者
张艺涵
刘雨喆
王阳
展祥皓
周舟
王丽珍
樊瑜波
ZHANG Yihan;LIU Yuzhe;WANG Yang;ZHAN Xianghao;ZHOU Zhou;WANG Lizhen;FAN Yubo(School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,China;National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices(Interdiscipline of Medicine and Engineering),School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,China;Key Laboratory of Biomechanics and Mechanobiology,Ministry of Education,School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,China;Key Laboratory of Innovation and Transformation of Advanced Medical Devices,Ministry of Industry and Information Technology,School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,China;Department of Biomedical Data Science,Stanford University,Stanford 94305,CA,US;Division of Neuronic Engineering,KTH Royal Institute of Technology,Stockholm 14152,Sweden)
出处
《爆炸与冲击》
北大核心
2025年第10期15-43,共29页
Explosion and Shock Waves
基金
国家自然科学基金(12302414)
北京市自然科学基金(7252287)
中国力学学会“蓄水池”项目(CSTAM 2023-XSC-HW3)
中央高校基本科研业务费专项资金(501QYJC2024110002)。
关键词
创伤性脑损伤
人类头部有限元模型
生物力学
头部防护
traumatic brain injury
finite element modeling of the human head
biomechanics
head protection
