摘要
牙周炎与多种全身系统性疾病密切相关,研究报道牙周炎对消化系统肿瘤具有促进作用。牙周致病菌可通过异位定植于消化系统肿瘤部位,直接调控肿瘤细胞、塑造促炎微环境、调节免疫反应,参与肿瘤的发生和发展。该文综述了牙周致病菌在促进消化系统肿瘤中的研究进展,旨在阐明其作用机制,并为相关研究向临床转化提供参考。
Periodontitis is closely associated with various systemic diseases,and emerging studies have reported its promotive effect on gastrointestinal tumors.Periodontal pathogens can ectopically colonize tumor sites in the gastrointestinal system,directly regulate tumor cells,shape a pro⁃inflammatory microenvironment,and modulate immune responses,thereby promoting tumor initiation and progression.This review summarizes the research progress of periodontal pathogens in promoting gastrointestinal tumors,aiming to elucidate their underlying mechanisms and provide insights for translational research and clinical applications.
作者
李昊谕
吴懿宽
丁佩惠
李晓军
LI Haoyu;WU Yikuan;DING Peihui;LI Xiaojun(Department of Periodontology,Stomatological Hospital,School of Stomatology,Zhejiang University School of Medicine,Zhejiang Provincial Clinical Research Center for Oral Diseases,Key Laboratory of Oral Biomedical Research of Zhejiang Province,Cancer Center of Zhejiang University,Hangzhou 310000,China)
出处
《口腔医学》
2025年第9期691-695,共5页
Stomatology
基金
国家自然科学基金(82170953)
浙江省重点研发项目领雁计划(2022C03088)
浙江省杰出青年科学基金(LR23H140001)
国家重点研发计划(2023YFC2506300)。
关键词
牙周炎
消化系统肿瘤
牙周致病菌
肿瘤进展
肿瘤微环境
periodontitis
gastrointestinal tumors
periodontal pathogens
tumor progression
tumor microenvironment
