摘要
目的:评估外用愈肤膏联合内服当归饮子治疗血虚风燥型慢性湿疹的疗效及安全性,并通过检测皮损处Caspase-14和丝聚蛋白(FLG) mRNA表达,探讨愈肤膏对皮肤屏障功能修复的影响,为院内制剂推广应用提供依据,进一步推广中药外用的“简、便、廉、效”优势。方法:采用随机对照研究设计,纳入56例血虚风燥型慢性湿疹患者,随机分为治疗组和对照组,各28例。治疗组外用愈肤膏联合内服当归饮子,对照组外用尿素维E乳膏联合内服当归饮子。分别于治疗前、治疗2 w及4 w后,记录湿疹面积及严重程度指数(EASI评分)、视觉模拟评分法(VAS评分)和皮肤病生活质量指数(DLQI评分)。选取各组6例患者检测治疗前后皮损处Caspase14和FLG mRNA表达。结果:两组患者年龄、性别、病程及各项评分差异无统计学意义(P>0.05),具可比性。治疗4 w后,治疗组EASI、VAS评分下降率显著高于对照组(P<0.05);治疗组在提高患者生活质量方面优于对照组(P<0.05);治疗组总有效率为92.86%,对照组为85.71%(P<0.05)。治疗组皮损处Caspase-14和FLG mRNA表达上调高于对照组(P<0.05)。结论:外用愈肤膏联合内服当归饮子治疗血虚风燥型慢性湿疹在改善皮损、缓解瘙痒和提高生活质量方面优于尿素维E乳膏,并能有效提高Caspase14和FLG mRNA表达,促进皮肤屏障功能修复,具有较好的临床应用前景。
Objective:To evaluate the efficacy and safety of external application of Yufu(愈肤)Cream combined with internal administration of Danggui(当归)Decoction in the treatment of chronic eczema in the patients with Xuexufengzao(血虚风燥)syndrome and explore the influence of Yufu Cream on skin barrier repair based on the mRNA levels of cysteinyl aspartate-specific proteinase 14(Caspase14)and filaggrin(Flg)in the skin lesions,thus providing a basis for the promotion and application of hospital preparations and promoting the advantages of simple and convenient application,low costs,and definite effects of the Chinese medicines for external application.Methods:A randomized controlled trial was conducted,in which 56 chronic eczema patients with Xuexufangzao syndrome were enrolled and randomized into a treatment group(n=28)and a control group(n=28).The patients in the treatment group were treated by external application of Yufu Cream combined with internal administration of Danggui Decoction,while those in the control group were treated by external application of urea vitamin E cream combined with internal administration of Danggui Decoction.The Eczema Area and Severity Index(EASI),Visual Analogue Scale(VAS),and Dermatology Life Quality Index(DLQI)scores were recorded before treatment as well as 2 weeks and 4 weeks after treatment.The mRNA levels of Caspasel4 and Flg in skin lesions before and after treatment were determined for 6 patients in each group.Results:Baseline data:There was no significant difference in the age,gender,course of disease,and scores between the two groups(P>0.05),which were comparable.Efficacy observation:①EASI score:After 4 weeks of treatment,the decrease in EASI score in the treatment group was higher than that in the control group(P<0.05).②VAS score:After 4 weeks of treatment,the treatment group outperformed the control group regarding the decline in VAS score(P<0.05).③DLQI score:The treatment group was superior to the control group in improving the quality of life of the patients(P<0.05).④Total response rate:The total response rate in the treatment group was 92.86%,which was higher than that(85.71%)in the control group(P<0.05).Laboratory indicators:The mRNA levels of Caspase-14 and FLG in skin lesions in the treatment group were higher than those in the control group(P<0.05).Conclusion:In the treatment of chronic eczema in the patients with Xuexufengzao syndrome,external application of Yufu Cream combined with internal administration of Danggui Decoction outperforms urea vitamin E cream in repairing skin lesions,relieving itching,and improving the quality of life.The combined therapy effectively upregulates the mRNA levels of Caspase 14 and Flg and promotes skin barrier repair,demonstrating a promising prospect in clinical application.
作者
邓婷涵
果珊珊
伍景平
程宏斌
DENG Tinghan;GUO Shanshan;WU Jingping;CHENG Hongbin(School of Clinical Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 610075;Department of Dermatology,Ya'an People's Hospital,Ya'an 625000;Department of Medical Cosmetology,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072;Department of Dermatology,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072)
出处
《中药药理与临床》
北大核心
2025年第7期63-66,共4页
Pharmacology and Clinics of Chinese Materia Medica
基金
四川省中医药管理局科学技术研究专项(编号:2023zd019)
四川省中医药管理局科学技术研究专项(编号:2024zd037)。
关键词
愈肤膏
慢性湿疹
尿素维E乳膏
血虚风燥型
皮肤屏障
Yufu(愈肤)Cream
Chronic eczema
Urea vitamin E cream
Xuexufengzao(血虚风燥)syndrome
Skin barrier
