摘要
在急性辐射损伤事件中,利用生物标志物迅速准确地评估受照剂量对于医学救治工作至关重要。近年来,随着代谢组学、免疫组学和基因组学等技术的应用,基因转录标志物、辐射代谢物等丰富了辐射生物标志物的范围。而微小RNAs(miRNAs)作为一类分子生物标志物,因其检测的简便性和高通量特性,在辐射损伤评估中显示出巨大潜力。本文综述了miRNAs的生物特性以及作为外周血辐射损伤生物标志物的研究进展。
In the case of acute radiation-induced damage,rapidly and accurately assessing the exposure dose using biomarkers is crucial to medical treatment.In recent years,with the application of technologies such as metabolomics,immunomics,and genomics,more radiation biomarkers have emerged based on gene transcription markers and radiation metabolites.MicroRNAs(miRNAs),a type of molecular biomarkers,have demonstrated great potential in radiation damage assessment due to their simplicity of tests and high throughput.This review summarized the biological characteristics of miRNAs and advances in research on peripheral blood miRNAs as biomarkers of radiation-induced damage.
作者
周瑞霞
李爽
Zhou Ruixia;Li Shuang(Key Laboratory of Radiological Protection and Nuclear Emergency,China CDC,National Institute for Radiological Protection,Chinese Center for Disease Control and Prevention,Beijing 10088,China)
出处
《中华放射医学与防护杂志》
北大核心
2025年第9期920-924,共5页
Chinese Journal of Radiological Medicine and Protection
基金
国家自然科学基金(82173464)。
