摘要
放射性肠损伤(RIII)常见于腹盆腔恶性肿瘤患者放疗后出现的肠道不良反应,不仅影响患者生活质量,还限制了放疗的临床疗效,但目前临床上针对RIII的防治方法尚未取得突破。天然植物产物普遍具有作用温和且不良反应小的优势,为防治RIII提供了大量潜在活性成分,包括多酚类、生物碱类、多糖类、皂苷类等。其作用机制包括抑制氧化应激、抑制细胞凋亡、调节炎症因子表达、保护肠隐窝干细胞、调节肠道菌群等。本综述探讨这些具有防治RIII效应的天然植物产物及其作用机制,为未来基于天然植物产物的药物研发提供理论依据。
Radiation-induced intestinal injury(RIII),a common intestinal adverse reaction to radiotherapy in patients with abdominal and pelvic malignant tumors,affects the quality of life of patients and limits the clinical efficacy of radiotherapy.However,there is no breakthrough in the prevention and treatment of RIII in clinical practice.Natural plant products generally have the advantages of mild effects and few adverse reactions,providing abundant potential active ingredients for the prevention and treatment of RIII,including polyphenols,alkaloids,polysaccharides,and saponins.The underlying mechanism includes inhibiting oxidative stress,inhibiting cell apoptosis,regulating the expression of inflammatory factors,protecting intestinal crypt stem cells,and regulating intestinal flora.The review summarized these natural plant products against RIII and explored its mechanisms of action,in order to provide a theoretical basis for future drug development based on natural plant products.
作者
黎思苑
谢黎伟
田野
Li Siyuan;Xie Liwei;Tian Ye(Department of Oncology,Zhangjiagang First People′s Hospital,Zhangjiagang 215600,China;Department of Radiotherapy,Second Affiliated Hospital of Soochow University,Suzhou 215004,China)
出处
《中华放射医学与防护杂志》
北大核心
2025年第9期911-919,共9页
Chinese Journal of Radiological Medicine and Protection
基金
苏州市青年科技项目(KJXW2021061)
张家港市科技计划项目(ZKS2123)。
关键词
天然产物
放射性肠损伤
放射治疗
Natural product
Radiation-induced intestinal injury
Radiotherapy
