摘要
目的 调查我国人群幽门螺杆菌(Helicobacter pylori,H.pylori)感染现状。方法 选取2020年1月至2021年12月解放军总医院第一医学中心(北京)、东部战区总医院(南京)、西部战区总医院(成都)、解放军联勤保障部队第940医院(兰州)及南部战区总医院(广州)首次接受尿素呼气试验(urea breath test,UBT)的受试者49224例,进行多中心横断面研究,比较不同性别、年龄及地域受试者的H.pylori感染率。结果 49224例受试者中,男23313例、女25911例,年龄18~<80岁,H.pylori感染者16873例,感染率为34.3%。男性受试者H.pylori感染率高于女性受试者(35.7%比33.0%);18~<30岁、30~<40岁、40~<50岁、50~<60岁、60~<70岁、70~<80岁受试者H.pylori感染率分别为35.4%、36.1%、35.6%、34.6%、30.3%、30.1%,其中30~<40岁受试者H.pylori感染率最高,此后随年龄增加H.pylori感染率呈下降趋势;兰州、广州、成都、南京、北京的受试者H.pylori感染率分别为45.0%、40.5%、36.4%、32.5%、28.4%,兰州地区H.pylori感染率最高,差异均有统计学意义(P<0.05)。结论 H.pylori感染在我国人群中普遍存在,影响超1/3的人群。男性高于女性,30~<40岁及兰州地区感染率最高,临床上应针对不同性别、年龄、地域对H.pylori感染进行重点防治。
Objective To explore the current status of Helicobacter pylori(H.pylori)infection in the Chinese population.Methods This multicenter,cross-sectional study was conducted,including 49224 patients who underwent the Urea Breath Test for the first time between January,2020 and December,2021 in the First Medical Center of Chinese PLA General Hospital(Beijing),General Hospital of Eastern Theater Command(Nanjing),General Hospital of Western Theater(Chengdu),the 940th Hospital of Joint Logistic Support Force of Chinese PLA(Lanzhou),and General Hospital of Southern Theater(Guangzhou).The H.pylori infection rates were compared among subjects stratified by gender,age,and region.Results Among the 49224 participants,there were 23313 males and 25911 females,the age ranged from 18 to<80 years old,16873 were infected with H.pylori,and the infection rate was 34.3%.The infection rate was significantly higher in males than in females(35.7%vs.33.0%).Regarding age stratification,the infection rates were 35.4%,36.1%,35.6%,34.6%,30.3%,and 30.1%in the 18~<30 years,30~<40 years,40~<50 years,50~<60 years,60~<70 years,and 70~<80 years groups,respectively.The highest infection rate was observed in the 30~<40 years group,followed by a significant decreasing trend with increasing age.In terms of regional distribution,the infection rates in Lanzhou,Guangzhou,Chengdu,Nanjing,and Beijing were 45.0%,40.5%,36.4%,32.5%,and 28.4%,respectively,with the highest rate in Lanzhou,and the difference was statistically significant,and the differences were statistically significant(P<0.05).Conclusions H.pylori infection is prevalent in the Chinese population,affecting more than one-third of individuals.Males have a higher infection rate than females,with the highest infection rates observed in the 30~<40 years age group and Lanzhou region.Clinically,targeted prevention and control strategies for H.pylori infection should be prioritized based on gender,age,and geographical differences.
作者
崔静
闵汉琛
汪芳裕
汤善宏
于晓辉
朱鸿武
赵亚刚
孙江珊
妥玉洁
杨云生
张晓梅
Cui Jing;Min Hanchen;Wang Fangyu;Tang Shanhong;Yu Xiaohui;Zhu Hongwu;Zhao Yagang;Sun Jiangshan;Tuo Yujie;Yang Yunsheng;Zhang Xiaomei(Department of Graduate School,Chinese PLA Medical School,Beijing 100853,China)
出处
《北京医学》
2025年第6期497-501,共5页
Beijing Medical Journal
关键词
幽门螺杆菌
感染率
尿素呼气试验
多中心研究
Helicobacter pylori(H.pylori)
prevalence
urea breath test
multicenter study
