摘要
目的探究某院二代抗精神病药物在门诊使用情况以及不合理用药。方法从许昌市建安医院精神科门诊2024年5-11月的处方中,随机抽取200张普通处方,作为研究对象。采用国际通行使用的药品,分析二代精神科药物的用药品种、联合用药、用药时间、以及不合理用药占比情况。结果随机抽检200份处方中,使用1种药品占比为52.5%(105/200),使用2种药品占比为33.5%(67/200),使用3种药品占比为10.0%(20/200),使用4种药品占比为3.0%(6/200),使用5种药品占比为1.0%(2/200)。联合用药情况,使用一代抗精神药占比为17.5%(35/200),使用二代抗精神药占比为88.0%(176/200),使用抑郁药占比为21.5%(43/200),使用情感稳定剂占比为4.5%(9/200)。处方用药时间0~7 d占比7.0%(14/200),8~14 d占比16.5%(33/200)。15~21 d占比28.5%(57/200),21~30占48.0%(96/200),超过7 d的占比76.5%(153/200),存在药物使用时间过长的现象。用药频率从大到小分别是利培酮、帕利哌酮、氯氮平、齐拉西酮、哌罗匹隆、阿立哌唑。抗精神病药物联合使用占比62.0%(124/200),镇静催眠类药物使用过量占比21.5%(43/200),处方用量偏大占比16.5%(33/200)。结论二代抗精神药物并未出现滥用情况,然而,药物的使用周期较长、合并用药现象较为突出,以及少数药品用量偏大,这些问题亟需针对性的规范与管理措施。
Objective To explore the use of second-generation psychiatric drugs in outpatient and the phenomenon of irrational drug use in Jian′an hospital of Xuchang city.Methods Two hundred ordinary prescriptions were randomly selected from the psychiatric outpatient department of a certain hospital from May to November 2024,using internationally recognized drugs,and to analyze the types of second-generation psychiatric drugs used,combination therapy,medication time,and the proportion of irrational medication.Results Among 200 randomly sampled cases,52.5%(105/200)used one drug,33.5%(67/200)used two drugs,10.0%(20/200)used three drugs,3.0%(6/200)used four drugs,and 1.0%(2/200)used five drugs.In the case of combination therapy,the proportion of using first generation antipsychotics is 17.5%(35/200),the proportion of using second-generation antipsychotics is 88.0%(176/200),the proportion of using antidepressants is 21.5%(43/200),and the proportion of using emotional stabilizers is 4.5%(9/200).Prescription medication time of 0~7 days accounts for 7.0%(14/200),and 8~14 days accounts for 16.5%(33/200).15~21 d accounted for 28.5%(57/200),21~30 d accounted for 48.0%(96/200),and those exceeding 7 d accounted for 79.2%,indicating a phenomenon of prolonged drug use.The frequency of medication,from highest to lowest,is risperidone,paliperidone,clozapine,ziprasidone,perospirone,and aripiprazole.The proportion of combined use of antipsychotic drugs is 62.0%(124/200),the proportion of excessive use of sedative and hypnotic drugs is 21.5%(33/200),and the proportion of excessive prescription dosage is 16.5%(43/200).Conclusion There has been no abuse of second-generation antipsychotic drugs,however,the drug′s usage cycle is relatively long,the phenomenon of concomitant use is prominent,and a few drugs have excessive usage.These issues urgently require targeted standardization and management measures.
作者
郭卉敏
Guo Huimin(Department of Pharmaceutical Equipment,Jian′an Hospital of Xuchang,Xuchang 461000,China)
出处
《实用医技杂志》
2025年第8期629-633,共5页
Journal of Practical Medical Techniques
关键词
精神药物
门诊部
医院
不合理用药现象
用药时间
Psychotropic drugs
Outpatient clinics,hospital
Irrational drug use phenomenon
Medication duration
