摘要
儿童闭塞性细支气管炎(bronchiolitis obliterans,BO)是儿科呼吸领域中一种严重且具有挑战性的疾病,对患儿呼吸健康危害极大。文章通过回顾儿童BO相关文献,从感染因素(病毒感染、支原体感染)、免疫异常(细胞免疫异常、体液免疫异常)和气道重塑(细胞外基质沉积、肌成纤维细胞活化)等方面深入剖析了儿童BO的病理机制,介绍了糖皮质激素治疗(全身应用糖皮质激素、吸入性糖皮质激素)、支气管扩张剂治疗(β_(2)受体激动剂、抗胆碱能药物)以及其他治疗方法(免疫抑制剂治疗、肺移植),并对未来的研究方向进行展望,旨在为临床医生提供全面且深入的理论依据,推动儿童BO防治水平的提升。
Bronchiolitis obliterans(BO)in children is a serious and challenging disease in the field of pediatric respiratory medicine,posing a significant threat to the respiratory health of affected children.This article,through a review of relevant literature on BO in children,conducts an in-depth analysis and summary of the pathological mechanisms of BO in children from aspects such as infectious factors(viral infection,mycoplasma infection),immune abnormalities(cellular immune abnormalities,humoral immune abnormalities),and airway remodeling(extracellular matrix deposition,myofibroblast activation).It also introduces treatment methods including glucocorticoid therapy(systemic glucocorticoids,inhaled glucocorticoids),bronchodilator therapy(β_(2)-receptor agonists,anticholinergic drugs),and other treatment approaches(immunosuppressant therapy,lung transplantation),and looks forward to future research directions.The aim is to provide clinicians with a comprehensive and in-depth theoretical basis and promote the improvement of prevention and treatment levels of BO in children.
作者
陈康小
林彬彬
CHEN Kangxiao;LIN Binbin(Department of Pediatrics,Wenzhou People's Hospital,Wenzhou Zhejiang 325000,China)
出处
《中国卫生标准管理》
2025年第14期191-194,共4页
China Health Standard Management
关键词
儿童
闭塞性细支气管炎
病理机制
呼吸健康
治疗
糖皮质激素
children
obstructive bronchitis
pathological mechanism
respiratory health
treatment
glucocorticoids
