摘要
目的观察原发性胃弥漫大B细胞淋巴瘤临床病理学及预后情况。方法选取厦门市第三医院2021年1月—2024年1月原发性胃弥漫大B细胞淋巴瘤患者30例,对患者基本信息以及临床病理学特征进行收集,分析预后情况及预后影响因素。结果弥漫成片的淋巴瘤系保养细胞浸润,同时破坏了胃黏膜,也减少了胃黏膜固有腺体,还有些患者肿瘤细胞破坏了胃壁肌层,而且存在较大的肿瘤细胞体积,也常存在核分裂象情况,散在坏死。癌抗原125(cancer antigen 125,CA125)水平正常患者5年生存率为94.44%,高于CA125上升患者的50.00%,差异有统计学意义(P<0.05)。乳酸脱氢酶(lactate dehydrogenase,LDH)水平正常患者5年生存率为68.75%,高于LDH水平上升患者的21.43%,差异有统计学意义(P<0.05)。化疗患者5年生存率为91.30%,高于手术联合化疗患者的42.86%,差异有统计学意义(P<0.05)。无骨髓侵犯患者5年生存率为90.91%,高于存在骨髓侵犯患者的25.00%,差异有统计学意义(P<0.05)。结论原发性胃弥漫大B细胞淋巴瘤临床病理学未体现出明显的不同,通过分析认为CA125水平、LDH水平、治疗方式、骨髓侵犯会影响患者预后,因此,在对患者预后判定期间需要充分考虑到以上危险因素,进而促进疗效提升。
Objective To observe the clinicopathology and prognosis of primary gastric diffuse large B-cell lymphoma.Methods A total of 30 patients with primary gastric diffuse large B-cell lymphoma(from January 2021 to January 2024)were selected from the Third Hospital of Xiamen.The basic information and clinicopathological features of the patients were collected and the influencing factors and prognosis were analyzed.Results Diffuse sheets of lymphoma were infiltrated by protective cells,which destroyed the gastric mucosa and reduced the inherent glands of the gastric mucosa.In some patients,the tumor cells destroyed the muscle layer of the gastric wall,and there were large tumor cell volume,and there were often mitotic images,which were scattered in necrosis.The 5-year survival rate of patients with normal levels of cancer antigen 125(CA125)was 94.44%,which was higher than the 50.00%of patients with elevated CA125 levels,and the difference was statistically significant(P<0.05).The 5-year survival rate of patients with normal lactate dehydrogenase(LDH)levels was 68.75%,which was higher than the 21.43%of patients with elevated LDH levels,and the difference was statistically significant(P<0.05).The 5-year survival rate of patients receiving chemotherapy alone was 91.30%,which was higher than the 42.86%of patients receiving surgery combined with chemotherapy,and the difference was statistically significant(P<0.05).The 5-year survival rate of patients without bone marrow involvement was 90.91%,which was higher than the 25.00%of patients with bone marrow involvement,and the difference was statistically significant(P<0.05).Conclusion There is no significant difference in the clinicopathology of primary gastric diffuse large B-cell lymphoma.The analysis suggests that CA125 level,LDH level,treatment mode and bone marrow invasion can affect the prognosis and survival of patients.Therefore,the above risk factors should be fully taken into account during the prognosis evaluation of patients,so as to promote the improvement of curative effect.
作者
周智俊
郑凤春
陈艳
ZHOU Zhijun;ZHENG Fengchun;CHEN Yan(Department of Pathology,the Third Hospital of Xiamen,Xiamen Fujian 361100,China)
出处
《中国卫生标准管理》
2025年第14期82-85,共4页
China Health Standard Management
关键词
原发性胃弥漫大B细胞淋巴瘤
临床病理学
癌抗原125
乳酸脱氢酶
治疗方式
骨髓侵犯
primary gastric diffuse large B-cell lymphoma
clinicopathology
carbohydrate antigen 125
lactate dehydrogenase
treatment
bone marrow invasion
