摘要
目的探讨血清代谢标志物在妊娠期糖尿病患者中的检测价值。方法选取2022年1月—2024年1月武穴市第一人民医院进行治疗的被诊断为糖尿病的孕妇72例为研究组研究对象,选取同时期来武穴市第一人民医院进行常规孕检的孕妇(排除妊娠期糖尿病)80例为对照组研究对象。比较2组孕妇孕早期(孕11~13周)的一般资料、生化指标及孕早期血清纤维凝胶蛋白(Ficolin-3)、成纤维细胞生长因子19(fibroblast growth factor 19,FGF19)及网膜素-1(Omentin-1)的水平。结果孕早期研究组孕妇的身体质量指数(body mass index,BMI)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、纤维蛋白原(fibrinogen,FBG)、甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)及低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)的水平分别为(22.61±1.98)kg/m^(2)、(7.01±0.97)%、(7.40±0.26)mmol/L、(1.63±0.38)mmol/L、(5.84±0.93)mmol/L、(2.55±0.53)mmol/L,对照组分别为(18.92±1.58)kg/m^(2)、(5.35±0.76)%、(4.12±0.18)mmol/L、(1.09±0.26)mmol/L、(3.95±1.04)mmol/L、(1.97±0.43)mmol/L,研究组均高于对照组,差异均有统计学意义(P<0.05)。研究组孕妇血清中Ficolin-3的水平为(35.00±2.84)μg/L,对照组为(19.95±2.00)μg/L,研究组高于对照组,差异有统计学意义(P<0.05);研究组孕妇血清中FGF19及Omentin-1的水平分别为(84.68±6.09)ng/L和(201.89±28.05)ng/mL,对照组分别为(150.08±9.73)ng/L和(348.72±24.02)ng/mL,研究组低于对照组,差异均有统计学差异(P<0.05)。孕早期孕妇血清Ficolin-3的水平与BMI、HbA1c、FBG、TG、TC及LDL-C的水平呈正相关;而血清FGF19及Omentin-1的水平与BMI、HbA1c、FBG、TG、TC及LDL-C的水平呈负相关(P<0.05)。血清中Ficolin-3的水平越高、FGF19及Omentin-1的水平越低都是孕早期孕妇发生妊娠期糖尿病的独立危险因素。结论孕早期孕妇血清中Ficolin-3、FGF19及Omentin-1的水平与妊娠期糖尿病的发生具有相关性,能为临床工作中对妊娠期糖尿病的早期预测提供一定的参考依据,以便临床医生能采取针对性的干预措施,降低妊娠期糖尿病的发生风险,进而使母婴结局得到改善。
Objective To explore the detection value of serum metabolic markers in gestational diabetes patients.Methods A total of 72 pregnant women diagnosed with diabetes who received treatment at Wuxue First People's Hospital from January 2022 to January 2024 were selected as the research subjects of the study group.A total of 80 pregnant women who underwent routine prenatal examination at Wuxue First People's Hospital during the same period(with gestational diabetes excluded)were selected as the research subjects of the control group.The general data,biochemical indicators,and the levels of serum Ficolin-3,fibroblast growth factor 19(FGF19),and Omentin-1 in the first trimester(11-13 weeks of gestation)were compared between the two groups of pregnant women.Results In the first trimester of pregnancy,the levels of body mass index(BMI),glycosylated hemoglobin(HbA1c),fibrinogen(FBG),triglyceride(TG),total cholesterol(TC),and low-density lipoprotein cholesterol(LDL-C)in the study group were(22.61±1.98)kg/m^(2),(7.01±0.97)%,(7.40±0.26)mmol/L,(1.63±0.38)mmol/L,(5.84±0.93)mmol/L,and(2.55±0.53)mmol/L,respectively;while those in the control group were(18.92±1.58)kg/m^(2),(5.35±0.76)%,(4.12±0.18)mmol/L,(1.09±0.26)mmol/L,(3.95±1.04)mmol/L,and(1.97±0.43)mmol/L,respectively.All the above indicators in the study group were higher than those in the control group,with statistically significant differences(P<0.05).The serum level of Ficolin-3 in the study group was(35.00±2.84)μg/L,compared with(19.95±2.00)μg/L in the control group;the level in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).The serum levels of FGF19 and Omentin-1 in the study group were(84.68±6.09)ng/L and(201.89±28.05)ng/mL,respectively,while those in the control group were(150.08±9.73)ng/L and(348.72±24.02)ng/mL,respectively;both indicators in the study group were lower than those in the control group,with statistically significant differences(P<0.05).In the first trimester of pregnancy,the serum level of Ficolin-3 in pregnant women was positively correlated with the levels of BMI,HbA1c,FBG,TG,TC,and LDL-C;in contrast,the serum levels of FGF19 and Omentin-1 were negatively correlated with the levels of BMI,HbA1c,FBG,TG,TC,and LDL-C.Moreover,a higher serum level of Ficolin-3 and lower serum levels of FGF19 and Omentin-1 were all independent risk factors for the development of gestational diabetes mellitus(GDM)in pregnant women during the first trimester.Conclusion There are clear correlation between the serum levels of Ficolin-3,FGF19 and Omentin-1 in pregnant women and the occurrence of gestational diabetes mellitus.It can provide a certain reference basis for the early prediction of gestational diabetes in clinical work,so that doctors can take targeted intervention measures to reduce the risk of gestational diatetes,and then can improve the outcome of maternal and infants.
作者
张公圣
陈杰琴
ZHANG Gongsheng;CHEN Jieqin(Department of Laboratory,Wuxue First People's Hospital,Wuxue Hubei 435400,China)
出处
《中国卫生标准管理》
2025年第14期30-34,共5页
China Health Standard Management
关键词
血清代谢标志物
妊娠期
糖尿病
检测价值
生化指标
纤维凝胶蛋白
serum metabolic markers
pregnancy period
diabetes mellitus
test value
biochemical index
fibrogel protein
