摘要
目的探讨三联预康复策略在改善乳腺癌新辅助化疗患者营养状况、负性情绪及生命质量的效果,以期为临床提供参考。方法采用类实验研究,便利抽样法选取2023年12月至2024年12月在甘肃省肿瘤医院已完成乳腺癌新辅助化疗的133例患者作为研究对象,按照人院顺序分为试验组66例和对照组67例。对照组采用常规健康指导,试验组在对照组的基础上增加三联预康复策略的护理方法。分别于干预前、干预3周后以及术后第2周比较2组患者血清白蛋白、体质量指数、焦虑、抑郁得分以及生命质量评分。结果2组最终各有64例完成研究,试验组年龄(49.50±10.46)岁,对照组年龄(50.42±12.50)岁,均为女性。试验组在干预3周后、术后第2周的血清白蛋白分别是(42.62±1.56)、(40.50±1.31)g/L,与对照组的(40.98±1.35)、(40.00±1.67)g/L比较差异均有统计学意义(t=-6.38、-1.89,均P<0.05);试验组在干预3周后、术后第2周的体质量指数分别是(24.02±1.35)、(23.48±1.72)kg/m^(2),与对照组的(22.98±1.72)、(22.50±1.31)kg/m^(2)比较差异均有统计学意义(t=-3.81、-3.61,均P<0.05);试验组在干预3周后、术后第2周的焦虑得分分别是(6.00±2.09)、(7.00±2.62)分,低于对照组的(7.00±2.26)、(8.00±2.76)分,差异均有统计学意义(t=2.60、2.10,均P<0.05);试验组在干预3周后、术后第2周的抑郁得分分别是(5.00±2.20)、(6.00±2.40)分,低于对照组的(6.00±2.02)、(7.00±2.09)分,差异均有统计学意义(t=2.68、2.52,均P<0.05);试验组在千预3周后、术后第2周的生命质量得分分别是(94.84±18.00)、(84.02±17.13)分,高于对照组的(82.00±18.75)、(72.03±17.10)分,差异均有统计学意义(t=-3.95、-3.96,均P<0.05)。结论三联预康复策略有助于减少乳腺癌新辅助化疗患者在营养方面的风险,缓解他们的负面情绪,并提升他们的生命质量,有望为乳腺癌新辅助化疗患者在术前的健康指导提供有价值的参考。
Objective To explore the effect of triple pre-rehabilitation strategy on improving nutritional status,negative emotions and quality of life in breast cancer patients undergoing neoadjuvant chemotherapy,so as to provide reference for clinical practice.Methods A quasi experimental research was adopted.A total of 133 patients who underwent neoadjuvant chemotherapy for breast cancer at Gansu Provincial Cancer Hospital between December 2023 and December 2024 were recruited as research participants.Patients were stratified into the experimental group(n=66)and control group(n=67)according to their admission sequence.The control group received routine health guidance,while the experimental group was provided with a triple pre-rehabilitation strategy based on the control group.The serum albumin,body mass index,anxiety,depression scores and quality of life scores were compared between the two groups before intervention,3 weeks after intervention and 2 weeks post-surgery.Results Totally 64 patients in each group completed the study.The age of the experimental group was(49.50±10.46)years,and that of the control group was(50.42±12.50)years.All of them were females.After a 3-week intervention,the serum albumin levels in the experimental group were(42.62±1.56)g/L,compared to(40.50±1.31)g/L 2 weeks post-surgery.In the control group,these values were(40.98±1.35)g/L and(40.00±1.67)g/L,respectively.The differences between groups were statistically significant(t=-6.38,-1.89,both P<0.05).Additionally,body mass index of the experimental group was(24.02±1.35)kg/m^(2)after the 3-week intervention and(23.48±1.72)kg/m^(2)2 weeks post-surgery,which were significantly higher than those of the control group(22.98±1.72)kg/m^(2)and(22.50±1.31)kg/m^(2),respectively(t=-3.81,-3.61,both P<0.05).The anxiety scores in the experimental group were(6.00±2.09)of 3 weeks after intervention and(7.00±2.62)2 weeks post-surgery,both of which were significantly lower than those in the control group(7.00±2.26)and(8.00±2.76),with statistically significant differences(t=2.60,2.10,both P<0.05).Additionally,the depression scores in the experimental group were(5.00±2.20)of 3 weeks after intervention and(6.00±2.40)2 weeks post-surgery,which were also significantly lower than those in the control group(6.00±2.02)and(7.00±2.09),with statistically significant differences(t=2.68,2.52,both P<0.05).Furthermore,the quality of life scores in the experimental group were(94.84±18.00)of 3 weeks after intervention and(84.02±17.13)2 weeks postsurgery,which were significantly higher than those in the control group(82.00±18.75)and(72.03±17.10),with statistically significant differences(t=-3.95,-3.96,both P<0.05).Conclusions The triple pre-rehabilitation strategy plays a crucial role in mitigating the nutritional risk for breast cancer patients undergoing neoadjuvant chemotherapy,alleviating their negative emotions,and enhancing their quality of life.This approach is anticipated to serve as a valuable reference for preoperative health guidance tailored to breast cancer patients undergoing neoadjuvant chemotherapy.
作者
杨其洲
王楠迪
马丽媛
李树坪
陈静
周江红
Yang Qizhou;Wang Nandi;Ma Liyuan;Li Shuping;Chen Jing;Zhou Jianghong(School of Nursing,Gansu University of Chinese Medicine,Lanzhou 730030,China;First Department of Breast Surgery,Gansu Provincial Cancer Hospital,Lanzhou 730050,China;Nursing Department of Gansu Provincial Cancer Hospital,Lanzhou 730050,China)
出处
《中国实用护理杂志》
2025年第29期2257-2264,共8页
Chinese Journal of Practical Nursing
基金
甘肃省卫生健康行业科研项目(GSWSHL2024-16)。
关键词
生活质量
三联预康复
乳腺癌新辅助化疗
营养风险
负性情绪
Quality of life
Triple pre-rehabilitation
Neoadjuvant chemotherapy for breast cancer
Nutritional risk
Negative emotions
