摘要
目的探究抗肿瘤药物静脉调配规范化管理对用药合理性的影响。方法选取2023年1月—2024年12月山东大学齐鲁医院10532份抗肿瘤药物医嘱处方为研究对象,根据时间分组,2023年1—12月的抗肿瘤药物医嘱处方设为对照组(n=5047),实施常规管理,2024年1—12月的抗肿瘤药物医嘱处方设为试验组(n=5485),实施规范化管理,比较2组不合理医嘱检出率、不合理医嘱分类情况。结果试验组不合理医嘱检出率为1.19%,低于对照组的2.87%,差异有统计学意义(P<0.001);试验组溶媒选择不合理、溶媒用量不合理、给药剂量不合理占比分别为0.57%、0.33%、0.04%,均低于对照组的1.35%、0.87%、0.18%,差异有统计学意义(P<0.05);试验组卡铂注射液、奥沙利铂注射液溶媒选择不合理占比分别为6.45%、12.90%,低于对照组的23.53%、35.29%,差异有统计学意义(P<0.05);试验组注射用吉西他滨溶媒用量不合理占比为5.56%,低于对照组的34.09%,差异有统计学意义(P<0.05);2组鸦胆子油乳注射液、斑蝥酸钠维生素B6注射液、注射用表柔比星给药剂量不合理占比对比差异无统计学意义(P>0.05)。结论实施抗肿瘤药物静脉调配规范化管理可降低不合理医嘱检出率,提升抗肿瘤药物静脉用药的合理性。
Objective To explore the influence of standardized management of intravenous administration of anti-tumor drugs on medication rationality.Methods A total of 10532 prescriptions of anti-tumor drugs from Qilu Hospital of Shandong University from January 2023 to December 2024 were selected as the research objects.They were grouped according to time.The medical order prescriptions of anti-tumor drugs from January to December 2023 were set as the control group(n=5047)and were subject to routine management.The medical order prescriptions of anti-tumor drugs from January to December 2024 were set as the experimental group(n=5485),and standardized management was implemented.The detection rate of unreasonable medical orders and the classification of unreasonable medical orders were compared between the two groups.Results The detection rate of unreasonable medical orders in the experimental group was 1.19%,which was lower than 2.87%in the control group,and the difference was statistically significant(P<0.001).The proportions of unreasonable solvent selection,unreasonable solvent dosage and unreasonable administration dosage in the experimental group were 0.57%,0.33%and 0.04%respectively,which were both lower than 1.35%,0.87%and 0.18%in the control group,and the differences were statistically significant(P<0.05).The proportions of unreasonable solvent selection for carboplatin injection and oxaliplatin injection in the experimental group were 6.45%and 12.90%respectively,which were lower than 23.53%and 35.29%in the control group,and the differences were statistically significant(P<0.05).The proportion of unreasonable dosage of gemcitabine solvent for injection in the experimental group was 5.56%,which was lower than 34.09%in the control group,and the difference was statistically significant(P<0.05).There were no statistically significant differences in the proportion of unreasonable administration dosage of Brucea javanica oil emulsion injection,sodium cantharidinate vitamin B6 injection and epirubicin for injection between the two groups(P>0.05).Conclusion The implementation of standardized management of intravenous administration of anti-tumor drugs can reduce the detection rate of unreasonable medical orders,and improve the rationality of intravenous use of anti-tumor drugs.
作者
段好庆
顾一珠
DUAN Haoqing;GU Yizhu(Department of Pharmacy(Department of Clinical Pharmacy),Qilu Hospital of Shandong University,Jinan Shandong 250000,China)
出处
《中国卫生标准管理》
2025年第13期133-137,共5页
China Health Standard Management
关键词
抗肿瘤药物
静脉调配
规范化管理
用药合理性
溶媒
给药剂量
anti-tumor drugs
intravenous administration
standardized management
edication rationality
menstruum
administration dosage
