摘要
目的分析胎盘生长因子(placental growth factor,PLGF)联合脐动脉收缩期峰值流速与舒张末期流速比值(peak systolic velocity/end diastolic velocity,S/D)对胎盘早剥的早期诊断效能。方法回顾性分析2020年1月至2023年5月于上饶卫生学校附属医院分娩的76例胎盘早剥孕妇的临床资料,并纳入胎盘早剥组;另选取同期于本院分娩的52名健康孕妇作为非胎盘早剥组。检测所有研究对象入院时PLGF水平与脐动脉S/D值,采用单因素及多因素Logistic回归分析孕妇胎盘早剥的影响因素,绘制受试者工作特征(receiver operating characteristic,ROC)曲线分析PLGF、脐动脉S/D值对胎盘早剥的早期诊断价值。结果胎盘早剥组PLGF水平低于非胎盘早剥组,脐动脉S/D值高于非胎盘早剥组,差异有统计学意义(P<0.05);多因素Logistic分析结果显示,PLGF水平低、脐动脉S/D值升高为胎盘早剥的独立影响因素(P<0.05);ROC曲线分析结果显示,PLGF、脐动脉S/D值联合诊断胎盘早剥的曲线下面积、灵敏度、特异度分别为0.941、90.79%、86.54%,诊断效能较高。结论PLGF、脐动脉S/D值可作为胎盘早剥早期的诊断指标,二者联合检测对胎盘早剥早期诊断具有较高的诊断效能,及早发现胎盘早剥并采取适当的治疗和控制措施可最大程度地减少并发症的发生风险,尽可能确保母胎的生命健康。
Objective To analyze the early diagnostic efficacy of placental growth factor(PLGF)combined with peak systolic velocity/end diastolic velocity(S/D)of umbilical artery for placental abruption.Methods The clinical data of 76 pregnant women with placental abruption who delivered in the Affiliated Hospital of Shangrao Health School from January 2020 to May 2023 were retrospectively analyzed and included in the placental abruption group;another 52 healthy pregnant women who delivered in our hospital during the same period were selected as the non-placental abruption group.PLGF levels and umbilical artery S/D of all research subjects at admission were detected.Univariate and multivariate Logistic regression analysis were used to analyze the influencing factors of placental abruption in pregnant women,and the receiver operating characteristic(ROC)curve was used to analyze the early diagnostic value of PLGF and umbilical artery S/D for placental abruption.Results The PLGF level in the placental abruption group was lower than that in the non-placental abruption group,umbilical artery S/D value was higher than that in the non-placental abruption group,and the differences were statistically significant(P<0.05);the results of multivariate Logistic analysis showed that low PLGF level and elevated S/D were independent risk factors for placental abruption(P<0.05).The results of ROC curve analysis showed that the area under the curve,sensitivity and specificity of combination of PLGF and umbilical artery S/D for diagnosing placental abruption were 0.941,90.79%and 86.54%,indicating high diagnostic efficacy.Conclusion PLGF and umbilical artery S/D can be used as early diagnostic indicators for placental abruption,the combined detection of PLGF and umbilical artery S/D has high diagnostic efficiency for the early diagnosis of placental abruption,early detection of placental abruption and appropriate treatment and control measures can minimize the risk of complications and ensure the life and health of the mother and fetus as much as possible.
作者
罗艳珍
李青
刘益芬
LUO Yanzhen;LI Qing;LIU Yifen(Shangrao Health Vocational College,Shangrao,Jiangxi,334000,China;Department of Ultrasound,Affiliated Hospital of Shangrao Health School,Shangrao,Jiangxi,334000,China)
出处
《当代医学》
2025年第8期91-95,共5页
Contemporary Medicine
