摘要
目的:探讨纤支镜肺泡灌洗术联合阿奇霉素与乙酰半胱氨酸在小儿重症肺炎患儿中的治疗效果。方法:选取2021年10月—2024年10月莆田市儿童医院收治的86例小儿重症肺炎患儿作为研究对象,按不同治疗方法分两组,各43例。对照组予以阿奇霉素与乙酰半胱氨酸治疗,观察组加用纤支镜肺泡灌洗术。比较两组治疗效果、症状消失时间、血气分析指标、炎症指标及不良反应发生率。结果:观察组治疗总有效率高于对照组;症状消失短于对照组;血氧分压(PaO_(2))、血氧饱和度(SaO_(2))高于对照组;动脉二氧化碳分压(PaCO_(2))、C反应蛋白(CRP)、白细胞计数(WBC)为、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)低于对照组,差异有统计学意义(P<0.05);组间不良反应发生率比较,差异无统计学意义(P>0.05)。结论:纤支镜肺泡灌洗术联合阿奇霉素与乙酰半胱氨酸可提高小儿重症肺炎治疗效果,加快症状消失,改善血气分析及炎症指标,安全有效。
Objective:To explore the therapeutic effect of fibrinoscopic alveolar lavage combined with azithromycin and acetylcysteine in children with pediatric severe pneumonia.Method:Retrospectively analyzing the data of 86 children with pediatric severe pneumonia admitted to Putian Children's Hospital from October 2021 to October 2024,and they were divided them into 2 groups,with 43 cases in each group according to different treatment methods.The control group was treated with azithromycin and acetylcysteine,and the observation group was added with fibrinoscopic alveolar lavage.Treatment effect,symptom disappearance time,blood gas analysis index,inflammation index and the incidence of adverse reactions of the two groups were compared.Result:The total effective rate of treatment in the observation group was higher than that in the control group.The disappearance of symptoms was shorter than that of the control group.The partial pressure of oxygen in blood(PaO_(2))and blood oxygen saturation(SaO_(2))were higher than those of the control group.Arterial partial pressure of carbon dioxide(PaCO_(2)),C-reactive protein(CRP),white blood cell count(WBC),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and procalcitonin(PCT)were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between groups(P>0.05).Conclusion:Fibrinoscopic alveolar lavage combined with azithromycin and acetylcysteine can improve the therapeutic effect of pediatric severe pneumonia,accelerate the disappearance of symptoms,improve the blood gas analysis and inflammatory indexes.It is safe and effective.
作者
黄小妹
许海妹
HUANG Xiaomei;XU Haimei(Putian Children's Hospital,Putian 351100,China;不详)
出处
《中外医学研究》
2025年第25期27-30,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
重症肺炎
纤支镜肺泡灌洗术
阿奇霉素
乙酰半胱氨酸
血气分析指标
炎症指标
Severe pneumonia
Fibrinoscopic alveolar lavage
Azithromycin
Acetylcysteine
Blood gas analysis index
Inflammatory indexes
