摘要
近年来2型糖尿病(T2DM)及非酒精性脂肪性肝病(NAFLD)患病率不断增加。两者常伴随发病,并互相推动疾病进程。中药治疗历史悠久,以其“多成分-多靶点、个性化”的特性而具有临床潜力。然中药治疗T2DM合并NAFLD的作用机制尚未完全明确。因此,现就胰岛素抵抗及脂代谢紊乱、氧化应激、促炎症因子生成及“肠-肝轴”紊乱等方面试阐述中药治疗T2DM合并NAFLD的疗效及作用机制,以期为临床用药提供理论依据。
The prevalence of type 2 diabetes mellitus(T2DM)and nonalcoholic fatty liver disease(NAFLD)has been increasing in recent years.These two conditions often occur concurrently and mutually promote the progression of each other.Traditional Chinese medicine(TCM)has a long history of treatment and has clinical potential due to its characteristics of“multi-component,multi-target,and individualized”.However,the mechanism of TCM in treating T2DM combined with NAFLD is not yet fully understood.Therefore,this article attempts to elaborate on the efficacy and mechanism of TCM in treating T2DM combined with NAFLD from aspects such as insulin resistance(IR)and lipid metabolism disorder,oxidative stress,pro-inflammatory factor production,and“gut-liver axis”disorder,in order to provide a theoretical basis for clinical medication.
作者
黄桢奇
周艳林
柯婷
肖洋
HUANG Zhenqi;ZHOU Yanlin;KE Ting;XIAO Yang(Shaanxi University of Chinese Medicine,Xianyang 712000,China;Shaanxi Provincial Hospital of Traditional Chinese Medicine,Xi’an 710003,China;Graduate School of China Academy of Chinese Medical Sciences,Beijing 100871,China)
出处
《陕西中医》
2025年第10期1437-1441,共5页
Shaanxi Journal of Traditional Chinese Medicine
基金
第二届全国名中医传承工作室建设项目[国中医药办人教函(2022)245号]
陕西省科学技术厅课题(2024SF-YBXM-522)
陕西省高水平中医药重点学科建设项目(SXZYYZDXK-2024006)。
关键词
2型糖尿病
非酒精性脂肪肝
作用机制
中药治疗
肠-肝轴
Type 2 diabetes mellitus
Nonalcoholic fatty liver disease
Molecular mechanisms
Traditional Chinese medicine treatment
Gut-liver axis
