摘要
血管衰老是指随着年龄的增长,血管出现一系列结构和功能改变的过程。内皮细胞功能障碍是血管衰老的早期表现。纤溶酶原激活物抑制剂1(PAI-1)已经被确定为衰老相关分泌表型,是内皮细胞衰老的标志物。PAI-1可通过促进血管内皮细胞衰老、血管周围纤维化、血栓形成和血管炎症的发生,参与血管衰老。系统研究PAI-1在血管衰老及其相关血管病变中的作用机制,可为血管衰老相关疾病的预防和治疗提供新的思路。
Vascular aging refers to the process of a series of structural and functional changes in blood vessels with aging.Endothelial dysfunction is an early manifestation of vascular aging.Plasminogen activator inhibitor 1(PAI-1)has been identified as a senescence-associated secretory phenotype and a marker of endothelial cell senescence.PAI-1 can participate in vascular aging by promoting vascular endothelial cell senescence,perivascular fibrosis,thrombosis and vascular inflammation.Systematic study on the mechanism of PAI-1 in vascular aging and its related vascular diseases can provide new ideas for the prevention and treatment of vascular aging-related diseases.
作者
王大君
王霞
张恬
刘炬
WANG Dajun;WANG Xia;ZHANG Tian;LIU Ju(Medical Research Center,The First Affiliated Hospital of Shandong First Medical University,Jinan 250014,China)
出处
《山东医药》
2025年第9期131-134,共4页
Shandong Medical Journal
基金
山东省自然科学基金青年项目(ZR2022QH341)。
