摘要
目的通过对2例脂蛋白肾小球病(LPG)患者的诊治经过及随访情况进行分析,探讨LPG的诊断与治疗方法。方法对2例LPG患者的临床症状、体征、实验室检查结果、治疗经过及随访情况进行回顾性分析。结果2例LPG患者均以“肾病综合征”收入住院,给予激素、免疫抑制剂治疗后效果不佳,最终通过肾活检病理诊断为LPG。将治疗方案调整为以降脂、降尿蛋白、保护肾功能为目的,1例血脂及尿蛋白逐渐降至正常,1例效果不佳,呈现肾病综合征表现。结论LPG诊断主要依靠肾脏病理学检查,治疗主要包括调脂、降压等方案,但疗效因患者而异。
Objective To analyze the diagnosis,treatment,and follow-up of two cases of lipoprotein glomerulopathy(LPG)in order to explore the diagnosis and treatment methods of LPG.Methods A retrospective analysis was conducted on the clinical symptoms,signs,laboratory examinations,treatment history,and follow-up of two LPG patients.Results Both patients were initially admitted to the hospital with nephrotic syndrome and received treatment with steroids and immunosuppressants,but the effect was not satisfactory.Eventually,they were diagnosed with LPG through renal biopsy pathology,and the treatment plan was adjusted to aiming at lipid-lowering,reducing urinary protein,and protecting renal function.One patient's blood lipids and urinary protein gradually decreased to normal,while the other patient had poor results and presented symptoms of nephrotic syndrome.Conclusions The diagnosis of LPG mainly relies on renal pathology.LPG treatment mostly includes lipid regulation and blood pressure reduction,but the efficacy varies from patient to patient.
作者
潘文旭
刘佳丽
王鲸竹
杨琨
PAN Wenxu;LIU Jiai;WANG Jingzhu;YANG Kun(Department of Internal Medicine 1,The Second Naval Hospital of Southern Theater Command of Chinese People's Liberation Army,Sanya China)
出处
《山东医药》
2025年第9期104-107,112,共5页
Shandong Medical Journal
基金
四川省南充市科技战略合作专项课题(20SXQT0287)。
关键词
脂蛋白肾病
肾病综合征
蛋白尿
高脂血症
lipoprotein glomerulopathy
nephrotic syndrome
proteinuria
hyperlipidemia
