摘要
神经退行性疾病主要是由大脑神经元的损伤引起的,包括阿尔茨海默症、帕金森病、亨廷顿病等,常见于中老年人群,给老龄化社会带来了巨大的负担。其病理涉及神经炎症、线粒体功能障碍和铁死亡等多种机制,其中神经炎症在病症出现前就已存在,并不断恶化,加重病情。香料化合物作为小分子物质,具有穿透血脑屏障的能力,其独特的多官能团结构能够通过抑制神经炎症来改善脑部微环境,进而发挥神经保护功能,为缓解和治疗神经退行性疾病提供了新的可能。该文介绍了神经退行性疾病中的神经炎症;根据香料化合物的结构进行分类,对比了不同香料化合物通过缓解神经炎症进而治疗神经退行性疾病的不同机制;最后指出了当前研究中存在的不足与局限,为未来治疗神经退行性疾病和相关研究提供了新方案和新方向。
Neurodegenerative diseases,such as Alzheimer's disease,Parkinson's disease,and Huntington's disease,are primarily caused by damage to brain neurons and commonly affect middle-aged and elderly individuals,posing a significant burden on aging societies.The pathologies of these diseases involve various mechanisms including neuroinflammation,mitochondrial dysfunction,and ferroptosis,of which neuroinflammation is present before the onset of the disease and worsens as it progresses.Flavor compounds have shown potential in penetrating the blood-brain barrier due to their small size.Their unique multifunctional structure allows them to improve the brain microenvironment by inhibiting neuroinflammation and exerting a neuroprotective effect,which presents a new possibility for alleviating and treating neurodegenerative diseases.In this review,neuroinflammation in neurodegenerative diseases was introduced.Various flavor compounds were then categorized based on their chemical structures,and the different mechanisms in neuroinflammation alleviation were compared.Finally,the limitations and shortcomings in current research were discussed,which provided new directions for future therapy of neurodegenerative diseases and related studies.
作者
于童
周露露
胡静
YU Tong;ZHOU Lulu;HU Jing(School of Perfume and Aroma Technology,Shanghai Institute of Technology,Shanghai 201418,China)
出处
《精细化工》
北大核心
2025年第10期2098-2106,2123,共10页
Fine Chemicals
基金
国家自然科学基金项目(22078196、22278268)
上海市自然科学基金项目(22ZR1460400)
上海市青年科技英才扬帆计划资助项目(23YF1446300)
上海应用技术大学引进人才科研启动项目(YJ2023-10)。
关键词
香料化合物
神经退行性疾病
神经炎症
抗炎
抗氧化
flavor compounds
neurodegenerative diseases
neuroinflammation
anti-inflammatory
antioxidation
