摘要
目的探讨血浆非对称二甲基精氨酸(ADMA)与系统性红斑狼疮(SLE)系统损害及子宫动脉血流值变化的相关性,研究血浆ADMA与子宫动脉多普勒(UtAD)指数对预测SLE不良妊娠结局的价值。方法纳入2022年3月至2023年11月在绵阳市中心医院风湿免疫科住院治疗的83例SLE患者,根据UtAD指数分为SLE合并子宫动脉阻力升高组(n=42)、SLE合并子宫动脉阻力正常组(n=41),另设同期健康对照组(n=30);记录SLE患者基本数据、临床症状、UtAD及实验室相关指标,采用酶联免疫吸附法(ELISA)测定血浆ADMA浓度。结果SLE合并子宫动脉阻力升高组的血浆ADMA水平、UtAD及不良妊娠发生率高于其余两组;血浆ADMA水平与UtAD升高相关(P<0.05);血浆ADMA水平联合UtAD对计算SLE患者不良妊娠的曲线下面积(AUC)为0.860,敏感度为88.34%,特异度为89.20%。结论血浆ADMA与SLE不良妊娠发生具有显著相关性,联合UtAD分析具有预测SLE不良妊娠结局的价值。
Objective To investigate the correlation between plasma asymmetric dimethylarginine(ADMA)level and systemic damage in patients with systemic lupus erythematosus(SLE),as well as changes in uterine artery hemodynamics,and to evaluate the predictive value of plasma ADMA level combined with uterine artery Doppler indices(UtAD)for adverse pregnancy outcomes in SLE patients.Methods A total of 83 SLE patients admitted to the Department of Rheumatology and Immunology at Mianyang Central Hospital from March 2022 to November 2023 were enrolled and divided into two groups based on UtAD:SLE with elevated uterine artery resistivity group(n=42)and SLE with normal uterine artery resistivity group(n=41).And 30 healthy individuals served as the control group.The basic data,clinical symptoms,UtAD,and relevant laboratory parameters were recorded.Plasma ADMA levels were measured using enzyme-linked immunosorbent assay(ELISA).Results The plasma ADMA level,uterine artery pulsatility indices,and the incidence of adverse pregnancy outcomes in the SLE with elevated uterine artery resistivity group were higher than those in the other two groups(P<0.05).The plasma ADMA level was correlated with the elevation of uterine artery Doppler indices(P<0.05).The area under the receiver operating characteristic(ROC)curve(AUC)of plasma ADMA level combined with uterine artery Doppler indices for predicting adverse pregnancy outcomes in SLE patients was 0.860,with a sensitivity of 88.34%and a specificity of 89.20%.Conclusion There is a significant correlation between plasma ADMA level and the occurrence of adverse pregnancy outcomes in SLE patients.The combined analysis of ADMA and uterine artery Doppler indices provides valuable predictive utility for pregnancy prognosis in SLE patients.
作者
李思吟
杨静
石娟
舒晓芳
沈娟
黄兴华
刘毅
Li Siyin;Yang Jing;Shi Juan;Shu Xiaofang;Shen Juan;Huang Xinghua;Liu Yi(Department of Rheumatology and Immunology,Mianyang Hospital Affiliated to School of Medicine,University of Electronic Science and Technology of China·Mianyang Central Hospital,Mianyang 621000,China;Department of Obstetrics and Gynecology,Mianyang Hospital Affiliated to School of Medicine,University of Electronic Science and Technology of China·Mianyang Central Hospital,Mianyang 621000,China;Department of Ultrasound Medicine,Mianyang Hospital Affiliated to School of Medicine,University of Electronic Science and Technology of China·Mianyang Central Hospital,Mianyang 621000,China;Department of Rheumatology and Immunology,West China Hospital,Sichuan University,Chengdu 610041,China)
出处
《成都医学院学报》
2025年第5期836-839,共4页
Journal of Chengdu Medical College
基金
四川省卫生健康委员会医学科技项目(No:21PJ180)
川北医学院2024年度四川省基层卫生事业发展研究中心资助项目(No:SWFZ24-Y-75)
绵阳市中心医院院级课题(No:2023YJ010)。
