摘要
目的基于“肝藏象学说”研究消瘿散结方穴位贴敷对气郁痰阻证甲状腺结节患者的应用疗效。方法选取2023年3月至2024年3月于成都中医药大学附属医院诊治的气郁痰阻证甲状腺结节患者140例为研究对象,随机分为对照组和干预组,每组各70例,对照组行常规干预,干预组在对照组基础上加用消瘿散结方穴位贴敷干预。采用双盲法进行观察,收集并比较干预前及干预3个月后两组的中医证候积分、临床疗效、影像学指标、甲状腺功能、焦虑状态[焦虑自评量表(SAS)]及治疗3个月后的欧洲五维健康量表(EQ-5D-5L)测量的健康状况。结果干预后,两组中医证候积分、甲状腺结节个数、甲状腺结节最大直径、甲状腺结节最大体积、SAS评分均呈现明显下降趋势,且干预组降幅明显大于对照组(P<0.05);干预组临床疗效、EQ-5D-5L中EQ-VAS评分明显优于对照组(P<0.05);干预组EQ-5D-5L中其余各项评分明显低于对照组(P<0.05)。结论基于“肝藏象学说”指导的消瘿散结方穴位贴敷法能提升气郁痰阻证甲状腺结节疗效,预防甲状腺结节扩增,且对甲状腺功能无明显影响,有效缓解患者焦虑状态和改善健康状态。
Objective To investigate the efficacy of Liver Zang-Fu Manifestation Theory[a traditional Chinese medicine(TCM)framework describing the liver's physiological functions and pathological reflections]guided acupoint application therapy with Xiaoying Sanjie formula(nodule-resolving formula)in patients with thyroid nodules presenting Qi stagnation and phlegm obstruction syndrome.Methods A total of 140 patients with thyroid nodules of Qi stagnation and phlegm obstruction syndrome treated at the Hospital of Chengdu University of TCM from March 2023 to March 2024 were divided into a control group(n=70)and an intervention group(n=70)based on a random number table.The control group received conventional treatment,while the intervention group received additional acupoint application of Xiaoying Sanjie formula.Observation was conducted using a double-blind method.TCM syndrome scores,clinical efficacy,imaging parameters(nodule number,maximum diameter,volume),thyroid function,anxiety status[assessed by Self-Rating Anxiety Scale(SAS)]before and after 3 months of intervention,as well as health status[assessed by European Quality of Life 5-Dimension 5-Level(EQ-5D-5L)questionnaire]after 3 months of intervention,were collected and compared between the two groups.Results After intervention,both groups exhibited significant reductions in TCM syndrome scores,nodule number,maximum diameter,nodule volume,and SAS scores(P<0.05),with greater reductions in the intervention group(P<0.05 for all comparisons).And compared with the control group,the intervention group demonstrated higher clinical efficacy rate,better EQ-VAS scores(P<0.05),and lower scores in other EQ-5D-5L dimensions(P<0.05).Conclusion Liver Zang-Fu Manifestation Theory guided acupoint application therapy with Xiaoying Sanjie formula enhances therapeutic efficacy,prevents nodule progression,alleviates anxiety,and improves health status in the treatment of patients with thyroid nodules presenting Qi stagnation and phlegm obstruction syndrome,without affecting thyroid function.
作者
刘娟
邱琳
蒋敏
付望
杨慧
刘桠
Liu Juan;Qiu Lin;Jiang Min;Fu Wang;Yang Hui;Liu Ya(Department of Endocrinology,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China)
出处
《成都医学院学报》
2025年第5期832-835,839,共5页
Journal of Chengdu Medical College
基金
四川省中医药管理局科学技术研究项目(No:2024MS293)。
关键词
肝藏象学说
气郁痰阻证
甲状腺结节
甲状腺功能
消瘿散结方穴位贴敷
疗效
Liver Zang-Fu Manifestation Theory
Qi stagnation and phlegm obstruction syndrome
Thyroid nodules
Thyroid function
Acupoint application of Xiaoying Sanjie formula
Efficacy
