摘要
目的:研究化疗联合免疫治疗对晚期非小细胞肺癌(NSCLC)患者外周血细胞因子的影响。方法:选取2024年1月—6月六盘水市人民医院肿瘤血液科收治的晚期NSCLC患者60例,根据治疗方案的不同分组,30例/组。对照组进行单纯化疗,观察组进行化疗联合免疫治疗。比较两组近期疗效、外周血细胞因子水平。结果:观察组疾病控制率相比对照组更高(P<0.05)。治疗后,观察组外周血细胞因子[白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)]检测值相比对照组均更低(P<0.05)。结论:对晚期NSCLC患者进行化疗联合免疫治疗,近期疗效较好,可有效下调外周血细胞因子水平。
Objective:To investigate the effect of chemotherapy combined with immunotherapy on peripheral blood cytokines in patients with advanced non-small cell lung cancer(NSCLC).Methods:A total of 60 patients with advanced NSCLC admitted to the Department of Oncology and Hematology,Liupanshui People's Hospital from January to June 2024 were selected and divided into two groups(30 cases each)based on different treatment regimens.The control group received chemotherapy alone,while the observation group received chemotherapy combined with immunotherapy.Short-term efficacy and peripheral blood cytokine levels were compared between the two groups.Results:The disease control rate in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the levels of peripheral blood cytokines[interleukin-1β(IL-1β),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)]in the observation group were significantly lower than those in the control group(P<0.05).Conclusion:Chemotherapy combined with immunotherapy for advanced NSCLC patients demonstrates favorable short-term efficacy and effectively downregulates peripheral blood cytokine levels.
作者
汤宏宇
吴学刚
丁萍
蒋海英
余青
TANG Hongyu;WU Xuegang;DING Ping;JIANG Haiying;YU Qing(Department of Oncology and Hematology,Liupanshui People's Hospital,Liupanshui 553000,China)
出处
《延边大学医学学报》
2025年第9期96-98,共3页
Journal of Medical Science Yanbian University
基金
六盘水市科技发展自筹经费项目(编号:52020-2024-0-39)。
关键词
晚期非小细胞肺癌
化疗
免疫治疗
外周血细胞因子
近期疗效
Advanced non-small cell lung cancer
Chemotherapy
Immunotherapy
Peripheral blood cytokines
Short-term efficacy
