摘要
目的:探讨大剂量放射治疗(简称为放疗)对脑转移瘤的局部控制效果,为临床提供有效的治疗策略。方法:选取2020年6月至2023年6月开封市肿瘤医院收治的60例脑转移瘤患者作为研究对象,随机分为对照组和研究组,每组各30例。对照组采用常规剂量放疗,研究组采用大剂量放疗。通过对比两组患者局部控制率、生存率以及不良反应发生率等指标,评估大剂量放疗的疗效及安全性。结果:研究组局部控制率为90.0%,显著高于对照组的70.0%(P<0.05)。研究组6个月、12个月、18个月生存率分别为93.3%、90.0%、73.3%,均高于对照组的83.3%、73.3%、50.0%(P<0.05)。放疗结束时,对照组生活质量核心问卷(QLQ-C30)评分下降,而研究组则有所升高,且研究组QLQ-C30评分高于对照组(P<0.05);随访期间,研究组QLQ-C30评分继续上升,与对照组相比差异有统计学意义(P<0.05)。研究组不良反应总发生率为70.0%,高于对照组的60.0%(P<0.05)。结论:大剂量放疗虽然会引起一些不良反应,但对脑转移瘤的局部控制效果较好,能显著提高患者生存率和生活质量。
Objective:To explore the local control efficacy of high-dose radiotherapy for brain metastases and provide an effective clinical treatment strategy.Methods:A total of 60 patients with brain metastases admitted to Kaifeng Cancer Hospital from June 2020 to June 2023 were selected as the study subjects and randomly divided into a control group and a study group,with 30 cases in each group.The control group received conventional-dose radiotherapy,while the study group received high-dose radiotherapy.The efficacy and safety of high-dose radiotherapy were evaluated by comparing the local control rate,survival rate,and incidence of adverse reactions between the two groups.Results:The local control rate in the study group was 90.0%,significantly higher than that in the control group(70.0%,P<0.05).The 6-month,12-month,and 18-month survival rates in the study group were 93.3%,90.0%,and 73.3%,respectively,all higher than those in the control group(83.3%,73.3%,and 50.0%,P<0.05).At the end of radiotherapy,the Quality of Life Core Questionnaire(QLQ-C30)score decreased in the control group but increased in the study group,with the study group’s QLQ-C30 score being higher than that of the control group(P<0.05).During follow-up,the QLQ-C30 score in the study group continued to rise,showing a statistically significant difference compared with the control group(P<0.05).The incidence of adverse reactions in the study group was 70.0%,higher than that in the control group(60.0%,P<0.05).Conclusion:Although high-dose radiotherapy may cause some adverse reactions,it demonstrates superior local control efficacy for brain metastases,significantly improving patient survival rates and quality of life.
作者
张瑞
冯高青
张民杰
孙慧娜
吴娅丽
ZHANG Rui;FENG Gaoqing;ZHANG Minjie;SUN Huina;WU Yai(First Ward of Radiotherapy Department,Kaifeng Cancer Hospital,Kaifeng 475003,China)
出处
《延边大学医学学报》
2025年第9期33-36,共4页
Journal of Medical Science Yanbian University
关键词
脑转移瘤
大剂量放疗
局部控制效果
生存率
不良反应
Brain metastases
High-dose radiotherapy
Local control efficacy
Survival rate
Adverse reactions
