摘要
目的探讨小而密低密度脂蛋白胆固醇(sd-LDL-C)/高密度脂蛋白胆固醇(HDL-C)比值与急性心肌梗死(AMI)患者行经皮冠状动脉介入(PCI)术后短期预后的关系。方法选取2020年1月—2023年12月呼和浩特市中医蒙医医院行PCI术的AMI患者218例。收集所有患者的临床资料和术前实验室指标检测结果,并检测PCI术前sd-LDL-C和HDL-C水平,计算sd-LDL-C/HDL-C比值。根据患者术后1个月的短期预后情况分为预后良好组(153例)和预后不良组(65例)。采用受试者工作特征(ROC)曲线评估各项指标判断AMI患者PCI术后短期预后不良的效能。结果预后良好组和预后不良组心肌梗死面积、吸烟史和高血压所占比例差异均有统计学意义(P<0.05),其他临床资料2个组之间差异均无统计学意义(P>0.05)。预后不良组与预后良好组低密度脂蛋白胆固醇(LDL-C)、sd-LDL-C、HDL-C水平和sd-LDL-C/HDL-C比值差异均有统计学意义(P<0.05),其他指标2个组之间差异均无统计学意义(P>0.05)。心肌梗死面积≥50%、有吸烟史、合并高血压、LDL-C升高、sd-LDL-C升高、HDL-C降低、sd-LDL-C/HDL-C比值升高是AMI患者PCI术后短期预后不良的危险因素(P<0.05)。LDL-C、sd-LDL-C、HDL-C、sd-LDL-C/HDL-C比值单项检测和联合检测模型判断AMI患者预后不良的曲线下面积(AUC)分别为0.651、0.868、0.850、0.919、0.934。结论sd-LDL-C/HDL-C比值与AMI患者PCI术后短期预后不良有关,可作为AMI患者PCI术后短期预后的评估指标之一。
Objective To investigate the relationship between the ratio of small and dense low-density lipoprotein cholesterol(sd-LDL-C)to high-density lipoprotein cholesterol(HDL-C)and the short-term prognosis of patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods A total of 218 AMI patients who underwent PCI in Hohhot Mongolian Hospital of Traditional Chinese Medicine from January 2020 to December 2023 were enrolled.The clinical data and preoperative laboratory determination results were collected,the levels of sd-LDL-C and HDL-C before PCI were determined,and the sd-LDL-C/HDL-C ratio was calculated.The patients were classified into good prognosis group(153 cases)and poor prognosis group(65 cases)based on the short-term(1 month)prognosis after PCI.Receiver operating characteristic(ROC)curve was used to evaluate the efficacy of various indicators in predicting the poor short-term prognosis of AMI patients after PCI.Results There was statistical significance in the proportions of myocardial infarction area,smoking history and hypertension between good prognosis group and poor prognosis group(P<0.05),while there was no statistical significance in the other clinical data between the 2 groups(P>0.05).There was statistical significance in the levels of low-density lipoprotein cholesterol(LDL-C),sd-LDL-C,HDL-C and sd-LDL-C/HDL-C ratio between poor prognosis group and good prognosis group(P<0.05),while there was no statistical significance in the other indicators between the 2 groups(P>0.05).Myocardial infarction area≥50%,smoking history,hypertension,elevated LDL-C,elevated sd-LDL-C,decreased HDL-C and elevated sd-LDL-C/HDL-C ratio were risk factors for the poor short-term prognosis of AMI patients after PCI(P<0.05).The areas under curves(AUC)of single and combined determinations of LDL-C,sd-LDL-C,HDL-C and sd-LDL-C/HDL-C ratio for predicting the prognosis of AMI patients were 0.651,0.868,0.850,0.919 and 0.934,respectively.Conclusions The sd-LDL-C/HDL-C ratio is associated with poor short-term prognosis in AMI patients after PCI,which can be used as one of the indicators for evaluating the short-term prognosis of AMI patients after PCI.
作者
王春红
WANG Chunhong(Department of Clinical Laboratory,Hohhot Mongolian Hospital of Traditional Chinese Medicine,Hohhot 010030,Inner Mongolia,China)
出处
《检验医学》
2025年第9期875-880,共6页
Laboratory Medicine
关键词
小而密低密度脂蛋白胆固醇
高密度脂蛋白胆固醇
急性心肌梗死
经皮冠状动脉介入治疗
预后
Small and dense low-density lipoprotein cholesterol
High-density lipoprotein cholesterol
Acute myocardial infarction
Percutaneous coronary intervention
Prognosis
