摘要
特发性肺间质纤维化(IPF)是一种原因不明的慢性肺间质性肺病。调查显示其发病率和死亡率正在逐年上升,但IPF病因尚未明确,其病理机制复杂,与多条信号通路及细胞因子有关。许多研究表明内质网(ER)应激、未折叠蛋白反应(UPR)通路可能在IPF发病中发挥关键作用。中医药在治疗IPF上具有独特优势,现代研究表明中药单体、中成药以及中药复方等可以通过调节内质网应激途径治疗肺纤维化该文总结中医药通过影响质网应激治疗肺纤维化的研究进展,揭示中医药治疗IPF的作用机制。
Idiopathic pulmonary fibrosis(IPF)is a chronic interstitial lung disease with an unknown etiology.Evidence indicates that both the incidence and mortality rates of IPF have been rising annually.Although extensive research,the exact etiology of IPF remains elusive,and its pathogenesis is complex,involving multiple signaling pathways and cytokines.Recent studies suggest that endoplasmic reticulum(ER)stress and the unfolded protein response(UPR)pathway may play crucial roles in the development and progression of IPF.Traditional Chinese medicine(TCM)has demonstrated unique therapeutic advantages in managing IPF.Modern pharmacological studies have revealed that TCM herbs,proprietary Chinese medicines,and herbal compounds can ameliorate pulmonary fibrosis by modulating ER stress.These findings contribute to a deeper understanding of the mechanisms underlying the therapeutic effects of TCM in IPF treatment.
作者
王开心
朱振刚
WANG Kaixin;ZHU Zhengang(First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;National Clinical Medical Research Center of Acupuncture and Moxibustion of Traditional Chinese Medicine,Tianjin 300381,China)
出处
《实用中医内科杂志》
2025年第8期64-69,共6页
Journal of Practical Traditional Chinese Internal Medicine
基金
国家自然科学基金项目(81673900)。
关键词
内质网应激
特发性肺间质纤维化
中医药
Endoplasmic reticulum stress
Idiopathic pulmonary fibrosis
Traditional Chinese Medicine
