摘要
目的探究低剂量电离辐射对放射工作人员甲状腺状况及激素水平的影响。方法选择2015—2022年在广州市某医院进行职业健康检查放射工作人员为研究对象,分析FT3、FT4、TSH水平,比较不同分组放射工作人员甲状腺异常状况。结果研究共纳入1152名研究对象,其中男性885名,占76.82%,女性267名,占23.18%,平均年龄为(35.26±10.16)岁。甲状腺异常发生率为9.38%,女性(13.86%)高于男性(8.02%),P<0.05。女性TSH(2.15±1.29)mIU/L高于男性(1.85±1.20)mIU/L,而女性FT3(5.10±0.64)pmol/L、FT4(15.84±2.32)pmol/L水平则低于男性[分别为:(5.23±0.63)pmol/L和(16.61±2.75)pmol/L,P<0.05]。工业应用工作人员FT3(5.25±0.63)pmol/L高于医学应用工作人员(5.10±0.63)pmol/L,而TSH(1.80±1.12)mIU/L则低于医学应用工作人员(2.15±1.37)mIU/L。FT4随年龄组和接害工龄升高而呈降低的趋势。多因素logistic回归分析显示性别是影响放射工作人员甲状腺异常状况的显著因素,女性工作人员更容易出现甲状腺异常状况(β=-0.62,P<0.05)。结论低剂量电离辐射可能对放射工作人员的甲状腺状况产生一定影响,特别是对女性的工作人员,需要进一步关注和研究。
Objective To investigate the effects of low-dose ionizing radiation on the thyroid status and hormone levels of radiation workers.Methods Radiation workers who underwent occupational health examinations at a hospital in Guangzhou from 2015 to 2022 were selected as the subjects of this study.The levels of FT3,FT4 and TSH were analyzed,and the thyroid abnormality status of radiation workers in different groups were compared.Results A total of 1152 participants were included in this study,consisting of 885(76.82%)males and 267(23.18%)females,with an average age of(35.26±10.16)years.The prevalence of thyroid abnormalities was 9.38%,which was significantly higher in females(13.86%)than in males(8.02%)(P<0.05).The TSH level of females[(2.15±1.29)mIU/L]was higher than that of males[(1.85±1.20)mIU/L],while the levels of FT3[(5.10±0.64)pmol/L]and FT4[(15.84±2.32)pmol/L]in females were lower than those in males[(5.23±0.63)pmol/L and(16.61±2.75)pmol/L,P<0.05].The FT3 of industrial workers[(5.25±0.63)pmol/L]was higher than that of medical workers[(5.10±0.63)pmol/L],while the TSH of industrial workers[(1.80±1.12)mIU/L]was lower than that of medical workers[(2.15±1.37)mIU/L].FT4 levels decreased with increasing age and duration of occupational exposure.Multivariable logistic regression analysis revealed that sex was a significant independent predictor of thyroid abnormalities among radiation workers.Female workers were more likely to experience thyroid abnormalities(β=−0.62,P<0.05).Conclusion Low-dose ionizing radiation may have a certain impact on the thyroid status of radiation workers,especially for female workers,which requires further attention and research.
作者
陈美琳
杨双玉
张燕
黄海波
王致
刘振中
王建宇
CHEN Meilin;YANG Shuangyu;ZHANG Yan;HUANG Haibo;WANG Zhi;LIU Zhenzhong;WANG Jianyu(School of Public Health,North Sichuan Medical College,Nanchong 637100,China;Key Laboratory of Occupational Environment and Health,Guangzhou 12 th People's Hospital,Guangzhou 510620,China)
出处
《中国辐射卫生》
2025年第4期590-594,共5页
Chinese Journal of Radiological Health
基金
广东省医学科学技术研究基金项目(C2023095)
广州医科大学科研能力提升计划项目(广医发【2023】16号)
广州市市校(院)企联合资助专题(广州市职业环境与健康重点实验室)(2023A03J0502)
广州市科学技术局重点研发计划项目(202206010061)。
