摘要
目的观察复方蓝棕片对前列腺增生患者行经尿道前列腺激光剜除术后膀胱刺激症的临床疗效。方法该研究为前瞻性研究,选取2024年1—12月通辽市人民医院收治的前列腺增生行激光剜除术患者80例为研究对象,采用随机数字表法分为研究组及对照组,各40例。对照组术后给予酒石酸托特罗定片0.2 mg,2次/d,口服。研究组在对照组的基础给予复方蓝棕果片0.5 g,3次/d,口服。两组患者术后均药物治疗4周。比较两组患者的临床疗效、国际前列腺症状评分(IPSS)、膀胱过度活动症评分(OABSS)、术后最大尿流率(Qmax)、排尿后残余尿量(PVR)、术后膀胱刺激症发生率等指标。结果术前两组患者IPSS、OABSS、Qmax、PVR等指标的差异均无统计学意义(均P>0.05)。术前对照组Qmax为(8.64±2.83)mL/s,IPSS为(25.10±4.37)分,OABSS为(10.52±1.87)分,PVR为(80.70±6.34)mL,研究组各指标分别为(9.12±2.95)mL/s、(24.60±4.53)分、(10.83±1.73)分、(80.10±5.61)mL;术后对照组各指标分别为(20.30±3.65)mL/s、(8.50±1.58)分、(4.09±0.52)分、(9.70±2.48)mL,研究组分别为(21.40±4.38)mL/s、(7.40±1.76)分、(1.71±0.36)分、(9.00±1.75)mL。两组患者Qmax明显提高,IPSS、OABSS、PVR均明显降低(均P<0.05),术后研究组IPSS、OABSS均较对照组明显下降,差异均有统计学意义(t=-3.28、-25.89,均P<0.05),Qmax、PVR比较差异均无统计学意义(均P>0.05)。术后研究组膀胱刺激症发生率[12.50%(5/40)]低于对照组[35.00%(14/40)](χ^(2)=8.64,P<0.05)。结论复方蓝棕果片治疗前列腺增生症经尿道激光剜除术患者能减轻术后前列腺症状及膀胱刺激症,有一定的临床疗效。
Objective To investigate the clinical efficacy of compound sabal berry tablets on overactive bladder symptoms in patients with benign prostatic hyperplasia after transurethral laser enucleation of the prostate.Methods This study was a prospective study.Eighty patients with benign prostatic hyperplasia who underwent laser enucleation at Tongliao People's Hospital from January 2024 to December 2024 were included in this study.The patients were randomly divided into a study group and a control group using the random number table method,with 40 patients per group.The control group received 0.2 mg of tolterodine tartrate tablets twice a day after surgery.The study group was given compound sabal berry tablets(0.5 g orally three times a day)in addition to the treatment provided to the control group.Both groups of patients were treated for 4 weeks after surgery.The clinical efficacy of the two groups was compared,including the International Prostate Symptom Score(IPSS),Overactive Bladder Symptom Score(OABSS),Maximum Postoperative Urinary Flow Rate(Qmax),Post-Void Residual(PVR),and the incidence of postoperative bladder irritative symptoms.Results The differences in the preoperative indicators,including IPSS,OABSS,Qmax,and PVR,between the two groups were not statistically significant(all P>0.05).Preoperatively,in the control group,Qmax was(8.64±2.83)mL/s,IPSS was(25.10±4.37),OABSS was(10.52±1.87),and PVR was(80.70±6.34)mL;in the study group,the respective values were(9.12±2.95)mL/s,(24.60±4.53),(10.83±1.73),and(80.10±5.61)mL.Postoperatively,in the control group,Qmax was(20.30±3.65)mL/s,IPSS was(8.50±1.58),OABSS was(4.09±0.52),and PVR was(9.70±2.48)mL,while in the study group,the respective values were(21.40±4.38)mL/s,(7.40±1.76),(1.71±0.36),and(9.00±1.75)mL.Postoperatively,both groups showed a significant increase in Qmax,while IPSS,OABSS,and PVR all significantly decreased(all P<0.05).Postoperatively,the IPSS and OABSS in the study group were significantly lower than those in the control group(t=-3.28,-25.89,both P<0.05).However,there were no statistically significant differences in Qmax and PVR between the two groups(both P>0.05).The incidence of bladder irritative symptoms in the study group[12.50%(5/40)]was significantly lower than that in the control group[35.00%(14/40),χ^(2)=8.64,P<0.05].Conclusions Compound sabal berry tablets can reduce postoperative prostate symptoms and overactive bladder symptoms in patients undergoing transurethral laser enucleation of the prostate for benign prostatic hyperplasia,demonstrating a certain clinical efficacy.
作者
杭盖
文泉
刘莹
郭云鹏
王玉阳
于志宇
陈博
Hang Gai;Wen Quan;Liu Ying;Guo Yunpeng;Wang Yuyang;Yu Zhiyu;Chen Bo(Department of Urology,Tongliao People's Hospital,Tongliao 028000,Inner Mongolia Autonomous Region,China)
出处
《中国基层医药》
2025年第9期1315-1319,共5页
Chinese Journal of Primary Medicine and Pharmacy
基金
内蒙古自治区公立医院联合基金(2023GLLH0386)。
关键词
前列腺增生
膀胱
过度活动性
中草药
疗效比较研究
酒石酸托特罗定
复方蓝棕果片
Prostatic hyperplasia
Urinary bladder,overactive
Drugs,Chinese herbal
Comparative effectiveness research
Tolterodine tartrate
Compound blue palmetto tablets
