摘要
反向离子迁移谱(inverse ion mobility spectrometry,IIMS)的分辨率相较于传统离子迁移谱(ion mobility spectrometry,IMS)提高了30%~60%。然而,IIMS的离子门驱动电源一般需要进行高压隔离,导致其结构复杂且成本较高。基于此,本研究设计开发了一款用于IIMS的离子门驱动控制电源,其具有结构简单、无需额外高压隔离、制作成本低以及控制方便等优点。经检测,该电源的脉冲上升和下降响应时间均达到了设计指标,可满足IIMS的信号检测需求。以IIMS的反应离子为研究对象进行实验验证,该电源的脉冲幅值和脉冲宽度对IIMS性能的影响符合理论分析,且分辨率较传统IMS提高了45%,与文献报道相符,进一步验证了该离子门驱动电源在IIMS仪器应用中的可行性。
Ion mobility spectrometry(IMS)is a trace detection technique.It realizes rapid separation and detection of ions by capitalizing on the disparities in the mobility velocities of ions in an electric field under atmospheric pressure.The ion gate is one of the core components for controlling the detection of IMS signals.Driving and controlling the ion gate effectively by means of the ion gate power supply is one of the main approaches to enhance the detection performance of IMS.The technology of inverse ion mobility spectrometry(IIMS)reverses the control mode of the ion gate in traditional IMS from“off-on-off”to“on-off-on”.As the ion gate remains open for an extended period,the drift region of the drift tube is filled with a continuous ion flow.When the ion gate is briefly closed,a charge-free depression peak emerges in the continuous ion flow.Due to the strong Coulomb repulsion among ions,the depression peak is narrowed,and the resolution of IIMS is increased by 30%to 60%compared to traditional IMS.Nonetheless,the ion gate drive power supply required for IIMS necessitates the incorporation of a high-voltage isolation circuit,which complicates the system architecture and increases associated costs.This research carried out a study on the power supply control technology for the IIMS ion gate.The proposed power supply was characterized by its simplified architecture,the elimination of additional high-voltage isolation circuits,reduced manufacturing costs,and improved ease of control.Testing results indicated that the pulse rise and fall response times of this power supply conform to the established design specifications and adequately fulfill the signal detection requirements of IIMS.Experimental validation utilizing the reactant ions of IIMS revealed that the effects of pulse amplitude and pulse width on IIMS performance align with theoretical predictions.Moreover,the resolution of IIMS improved by 45%in comparison to traditional IMS,thereby corroborating reported literature and reinforcing the feasibility of this ion gate drive power supply for IIMS applications.
作者
黎皖君
罗元江
孔令文
郝家焕
李阳
夏磊
刘亚伟
沈成银
黄超群
储焰南
LI Wan-jun;LUO Yuan-jiang;KONG Ling-wen;HAO Jia-huan;LI Yang;XIA Lei;LIU Ya-wei;SHEN Cheng-yin;HUANG Chao-qun;CHU Yan-nan(Institutes of Physical Science and Information Technology,Anhui University,Hefei 230601,China;Anhui Province Key Laboratory of Medical Physics and Technology,Institute of Health and Medical Technology,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,China)
出处
《质谱学报》
北大核心
2025年第5期554-561,I0002,共9页
Journal of Chinese Mass Spectrometry Society
基金
国家自然科学基金(62171433)
安徽省重点研发计划(2022a05020034)
中国科学院合肥研究院院长基金高技术创新项目(YZJJ202305-CX)
中国科学院合肥研究院院长基金高技术探索项目(YZJJ202405-TS)。
