摘要
目的应用冠状动脉计算机断层扫描(CCTA)分析无心血管疾病症状T2DM患者冠状动脉粥样硬化(CAS)特征及性别间差异。方法检索2019年3所医院体检中心电子病历系统中T2DM患者178例,均为无心血管疾病症状体检者,因CAS高危因素行CCTA检查,男105例,女73例,比较不同性别患者一般资料及生化指标,Logistic回归分析T2DM患者出现CAS高危征象的影响因素,比较男、女性不同DM病程患者冠脉受累积分(SIS)≥4和节段狭窄积分(St.S)≥3发生率。结果女性T2DM患者年龄、高血压病占比高于男性(P<0.05),BMI、吸烟史、TG、TC/HDL-C、SIS≥4占比低于男性(P<0.05)。Logistic回归分析显示,高血压病程是T2DM患者发生CAS高危征象的影响因素。女性DM病程5~15年SIS≥4占比高于<5年(P<0.05),>15年SIS≥4占比低于<5年(P<0.05)。结论无心血管病症状T2DM患者不同性别间CAS高危征象发生率存在差异,女性受累节段数量与DM病程相关。
Objective To analyze the characteristics of coronary atherosclerosis(CAS)and the gender differences in type 2 diabetes mellitus(T2DM)patients without cardiovascular disease symptoms using coronary artery computed tomography(CCTA).Methods A total of 178 asymptomatic individuals with T2DM who underwent CCTA examination due to CAS risk factors were included in this analysis in 2019,and they were divided into male group(n=105)and female group(n=73)according to sex.The general data and biochemical indicators of patients of different genders were compared.Logistic regression was used to analyze the influencing factors of high-risk signs of CAS in patients with T2DM.The incidences of coronary artery involvement score(SIS)≥4 and segmental stenosis score(St.S)≥3 in male and female patients with different courses of DM were compared.Results The age and the proportion of hypertension in female patients with T2DM were higher than those in male patients(P<0.05),while the body mass index(BMI),smoking history,triglyceride(TG),total cholesterol(TC)/high-density lipoprotein cholesterol(HDL-C),and proportions of SIS≥4 were lower than those in male patients(P<0.05).Logistic regression analysis showed that the hypertension duration was an influencing factor for the occurrence of high-risk signs of CAS in patients with T2DM.The proportion of SIS≥4 in the female DM duration was higher than<5 years(P<0.05),and the proportion of SIS≥4 in>15 years was lower than<5 years(P<0.05).Conclusions The incidence of CAS high-risk signs in T2DM patients without cardiovascular symptoms is different between different sexes,the number of affected segments in women was related to the DM duration.
作者
赵林芬
张帆
李涛
徐崧
张晶
张兴华
杨立
ZHAO Linfen;ZHANG Fan;LI Tao(Department of Radiology,Wujin Affiliated Hospital,Nanjing University of Chinese Medicine,Changzhou 213161,China)
出处
《中国糖尿病杂志》
北大核心
2025年第8期566-571,共6页
Chinese Journal of Diabetes
基金
国家自然科学基金(81371547)
海南省重点研发计划资助项目(ZDYF2019169)。
