摘要
目的:探讨益母草注射液联合欣母沛在预防剖宫产宫缩乏力产妇产后出血中的应用价值。方法:选取符合标准的剖宫产宫缩乏力产妇110例,随机分为欣母沛组、草益母草联合组,各55例。欣母沛组剖宫产后给予欣母沛预防产后出血,益母草联合组剖宫产后给予益母草注射液联合欣母沛预防产后出血。比较2组临床疗效、产后出血量、凝血功能[凝血酶原时间(PT)、纤维蛋白原(FIB)、部分活化凝血活酶时间(APTT)、D-二聚体(D-D)]、血液动力学指标[心率、舒张压、收缩压]、应激反应指标[去甲肾上腺素(NE)、过氧化氢酶(CAT)、肾上腺素(AD)、丙二醛(MDA)]及不良反应。结果:益母草联合组临床总有效率为94.55%,高于欣母沛组的81.82%(P<0.05);益母草联合组产后 2 h和产后24 h出血量少于欣母沛组(P<0.05);治疗后,益母草联合组PT、FIB、APTT、D-D低于欣母沛组(P<0.05);益母草联合组心率高于欣母沛组,舒张压、收缩压低于欣母沛组(P<0.05);益母草联合组MDA低于欣母沛组,血清NE、CAT、AD水平高于欣母沛组(P<0.05)。2组不良反应发生率比较,无明显差异(P>0.05)。结论:益母草注射液联合欣母沛可减少剖宫产产后出血量,改善患者凝血功能,减轻应激损伤,维持血液动力学稳定,且安全性高。
Objective:To investigate the value of Yi Mu Cao injection combined with Xin Ma Pei in preventing postpartum hemorrhage in women undergoing cesarean section with uterine atony.Methods:110 women with cesarean section atony who met the criteria were randomly divided into a Xin Ma Pei group and a Yi Mu Cao combined group,55 cases in each group.The Xin Ma Pei group received Xin Ma Pei after cesarean section for postpartum hemorrhage prevention,while the Yi Mu Cao combined group received Yi Mu Cao injection combined with Xin Ma Pei for postpar-tum hemorrhage prevention.The two groups were compared in terms of clinical efficacy,postpartum hemorrhage vol-ume,coagulation function(prothrombin time(PT),fibrinogen(FIB),activated partial thromboplastin time(APTT),D-dimer(DD)),hemodynamic parameters(heart rate,diastolic blood pressure,systolic blood pressure),stress response parameters(norepinephrine(NE),catalase(CAT),epinephrine(AD),malondialdehyde(MDA)),and adverse reactions.Results:The total clinical efficacy rate of the motherwort combination group was 94.55%,higher than the 81.82%of the hemabate group(P<0.05).The motherwort combination group had less blood loss 2 and 24 hours after delivery than the hemabate group(P<0.05).After treatment,the motherwort combination group had lower PT,FIB,APTT,and D-D val-ues than the hemabate group(P<0.05).The motherwort combination group had a higher heart rate,and lower diastolic and systolic blood pressures than the hemabate group(P<0.05).The motherwort combination group had a lower MDA level than the hemabate group,and higher serum NE,CAT,and AD levels than the hemabate group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Motherwort injection combined with hemabate can reduce postpartum blood loss after cesarean section,improve coagulation func-tion,alleviate stress injury,maintain hemodynamic stability,and has a high safety profile.
作者
李丽
史天云
杨金丛
LI Li;SHI Tianyun;YANG Jincong(Nanzhao County Maternal and Child Health Hospital,He’nan Nanzhao 474666,China;Nanyang First People’s Hospital,He’nan Nanyang 473000,China)
出处
《中医药临床杂志》
2025年第9期1846-1850,共5页
Clinical Journal of Traditional Chinese Medicine
基金
河南省医学科技攻关联合共建项目(LHGJ20212817)。
关键词
剖宫产
产后出血
益母草注射液
欣母沛
凝血功能
血液动力学
Cesarean section
Postpartum hemorrhage
Motherwort injection
Hemoperitoneum
Coagulation func-tion
Hemodynamics
