摘要
蛋白质翻译后修饰(PTMs)是细胞调控的重要机制,通过酶促反应或其他生化途径向特定氨基酸残基引入修饰基团,进而改变蛋白质的空间结构、定位及生物学功能。该过程广泛发生于细胞核、细胞质、内质网和高尔基体等多种细胞器中,几乎参与细胞生命活动的全过程。PTMs可通过调控水生生物内部蛋白质功能,对其生长发育具有关键作用。然而,目前关于PTMs在水生生物中的系统性研究仍较为匮乏。文章综述了水生生物中常见的PTMs类型(包括磷酸化、泛素化、乙酰化、巴豆酰化及糖基化),探讨其生物学效应,并展望未来的研究方向,为水生生物蛋白质修饰研究提供参考。
Protein post-translational modification(PTMs)serves as a critical cellular regulatory mechanism,which alters protein structure,localization and function by covalently attaching specific chemical groups to amino acid residues through enzymatic reactions.These modifications extensively occur in diverse organelles such as the nucleus,cytoplasm,endoplasmic reticulum,and Golgi apparatus,participating in nearly all cellular life processes.PTMs play essential roles in regulating protein functions and promoting the growth and development of aquatic organisms.Nevertheless,systematic investigations on PTMs in aquatic species remain insufficient.This review summarizes prevalent PTMs types(including phosphorylation,ubiquitination,acetylation,crotonylation,and glycosylation)in aquatic organisms,elucidates their biological effects,and proposes future research directions,aiming to provide references for related studies.
作者
侯伟燕
冼健安
鲁耀鹏
李军涛
徐彤
张泽龙
顾志峰
郑佩华
HOU Weiyan;XIAN Jianan;LU Yaopeng;LI Juntao;XU Tong;ZHANG Zelong;GU Zhifeng;ZHENG Peihua
出处
《饲料研究》
北大核心
2025年第16期175-180,共6页
Feed Research
基金
海南省自然科学基金(项目编号:323MS085)
社会公益类科研机构改革专项(项目编号:ITBBQDF2023006)。
关键词
蛋白质翻译后修饰
磷酸化
乙酰化
泛素化
水生生物
protein post-translational modification
phosphorylation
acetylation
ubiquitination
aquatic organisms
