摘要
目的:观察玉屏风颗粒联合布地奈德治疗咳嗽变异性哮喘(CVA)患儿的效果。方法:回顾性分析2022年1—12月该院收治的100例CVA患儿的临床资料,按照治疗方法不同将其分为对照组和观察组各50例。对照组给予布地奈德雾化吸入治疗,观察组在对照组基础上联合玉屏风颗粒治疗。比较两组临床疗效,治疗前后肺功能指标[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC),FEV_(1)/FVC、呼气流量峰值(PEF)]水平、炎性因子[C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)]水平,以及不良反应发生率。结果:观察组治疗总有效率为94.00%(47/50),高于对照组的76.00%(38/50),差异有统计学意义(P>0.05);治疗后,两组FEV_(1)、FVC、FEV_(1)/FVC、PEF水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组CRP、PCT、IL-6水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:玉屏风颗粒联合布地奈德治疗CVA患儿,可提高临床疗效和肺功能,减轻机体炎症反应,效果优于单纯布地奈德治疗。
Objective:To observe effects of Yupingfeng granules combined with Budesonide in treatment of children with cough variant asthma(CVA).Methods:The clinical data of 100 children with CVA admitted to this hospital from February 2022 to June 2024 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,50 cases in each group.The control group was treated with Budesonide atomization inhalation,while the observation group was treated with Yupingfeng granules on the basis of that of the control group.The clinical efficacy,the levels of lung function indexes[forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC),FEV_(1)/FVC,peak expiratoryflow(PEF)]and inflammatory factors[C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 94.00%(47/50),which was higher than 76.00%(38/50)of the control group,and the difference was statistically significant(P>0.05).After treatment,the levels of FEV_(1),FVC,FEV_(1)/FVC and PEF in the two groups were higher than those before treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of CRP,PCT and IL-6 in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Yupingfeng granules combined with Budesonide in the treatment of the children with CVA can improve the clinical efficacy and the lung function,and reduce the body’s inflammatory response.Moreover,it is superior to simple Budesonide treatment.
作者
王慧
李艳玲
赵娟娟
WANG Hui;LI Yanling;ZHAO Juanjuan(Department of Pharmacy of Kaifeng Children’s Hospital,Kaifeng 475000 Henan,China)
出处
《中国民康医学》
2025年第19期118-120,共3页
Medical Journal of Chinese People’s Health
关键词
咳嗽变异性哮喘
肺功能
炎性因子
不良反应
Cough variant asthma
Lung function
Inflammatory factor
Adverse reaction
