摘要
目的:观察银杏叶提取物片联合卡巴拉汀治疗血管性认知障碍(VCI)的效果。方法:78例随机分为参照组和研究组各39例。两组均给予卡巴拉汀治疗,研究组加用银杏叶提取物片治疗。结果:总有效率研究组高于参照组(P<0.05)。治疗后ADL、MoCA、MMSE评分研究组较参照组高(P<0.05)。研究组CBV、CBF值大于参照组而MTT值小于参照组(P<0.05)。治疗后两组血清VEGF、NO、bFGF水平高于治疗前而ET-1水平低于治疗前,且研究组改善大于参照组(P<0.05)。治疗后研究组血清AOPP、MDA水平低于参照组而T-AOC、GSH-Px水平高于参照组(P<0.05)。不良反应发生率两组比较差异无统计学意义(P>0.05)。结论:银杏叶提取物片联合卡巴拉汀治疗VCI效果较好。
Objective:To observe the effect of Ginkgo Biloba Extract Tablets combined with rivastigmine in the treatment of vascular cognitive impairment(VCI).Methods:Seventy-eight cases were randomly divided into the reference group and the study group,with 39 cases in each group.Both groups were treated with rivastigmine,and the study group was treated with ginkgo biloba extract tablets in addition.Results:The total effective rate of the study group was higher than that of the reference group(P<0.05).After treatment,the scores of ADL,MoCA and MMSE in the study group were higher than those in the reference group(P<0.05).The CBV and CBF values of the study group were higher than those of the reference group,while the MTT value was lower than that of the reference group(P<0.05).After treatment,the levels of serum VEGF,NO and bFGF in the two groups were higher than those before treatment,while the level of ET-1 was lower than that before treatment,and the improvement in the study group was greater than that in the reference group(P<0.05).After treatment,the levels of serum AOPP and MDA in the study group were lower than those in the reference group,while the levels of T-AOC and GSH-Px were higher than those in the reference group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Ginkgo Biloba Extract Tablets combined with rivastigmine is effective in the treatment of VCI.
出处
《实用中医药杂志》
2025年第8期1662-1665,共4页
Journal of Practical Traditional Chinese Medicine
关键词
血管性认知障碍
银杏叶提取物片
卡巴拉汀
Vascular cognitive impairment
Ginkgo Biloba Extract Tablets
Kabalatin
