摘要
HHV8阴性原发性渗出性淋巴瘤(Primary Effusion Lymphoma,PEL)是一种罕见的非霍奇金淋巴瘤(Non-Hodgkin Lymphoma,NHL)亚型。本文报道1例以“大量心包积液”为首发症状的HHV8阴性原发性渗出性淋巴瘤,经心包积液蜡块病理诊断。患者接受蛋白酶体抑制剂联合减低剂量化疗,4个疗程后病情改善,随后定期行心包积液引流对症治疗。截止2024年10月,患者发病后已存活11个月。该疾病发病率极低,目前尚无统一的规范化诊疗方案,且现有的治疗方案疗效欠佳。此报道对HHV8阴性原发性渗出性淋巴瘤的临床诊疗具有重要的借鉴意义。
HHV8 negative primary exudative lymphoma(PEL)is a rare subtype of non Hodgkin’s lymphoma(NHL).This article reports a case of HHV8 negative primary exudative lymphoma with“massive pericardial effusion”as the initial symptom.The pathological diagnosis of the pericardial effusion wax block was“HHV8 negative primary exudative lymphoma”.The patient received proteasome inhibitors combined with low-dose chemotherapy,and after 4 chemotherapy courses,the condition improved.Subsequently,regular pericardial effusion drainage was performed for symptomatic treatment.As of October 2024,the patient has survived for 11 months after the onset of the disease.The incidence rate of the disease is extremely low.At present,there is no unified standardized diagnosis and treatment plan,and the existing treatment plan has poor efficacy.This case provides an in-depth study and report on HHV8 negative primary exudative lymphoma,which has important reference significance for clinical diagnosis and treatment.
作者
朱夏吟
张烨
林杰
Zhu Xiayin;Zhang Ye;Lin Jie(Zhejiang Taizhou Hospital,Taizhou 317000,China)
出处
《浙江实用医学》
2025年第3期202-206,227,共6页
Zhejiang Practical Medicine
基金
浙江省医药卫生科技计划项目(2025KY445),台州市科技局计划项目(24ywb28)。
