摘要
目的观察雷公藤方雾化熏蒸对干眼的临床疗效。方法纳入2022年5月—2022年12月就诊于中国中医科学院眼科医院的干眼患者44例(44只眼),随机分为治疗组和对照组各22例(22只眼),最终均纳入20例(20只眼)。试验组予雷公藤方雾化熏蒸联合0.1%玻璃酸钠眼液点眼,对照组予安慰剂雾化熏蒸联合0.1%玻璃酸钠眼液点眼,2组均治疗28 d。分别于治疗前后测量2组患者的眼表疾病指数(OSDI)评分、泪膜破裂时间(BUT)、泪液分泌试验(SⅠT)、泪河高度(TMH)、角膜荧光素染色(FL)评分。结果(1)OSDI评分:2组治疗后OSDI评分均低于治疗前,差异均有统计学意义(t_(试验组)=-5.945、t_(对照组)=-4.559,均P=0.000)。治疗后,2组间OSDI比较,差异无统计学意义(P>0.05)。(2)BUT:2组治疗后BUT均较治疗前延长,差异均有统计学意义(Z_(试验组)=3.734,P=0.000;Z_(对照组)=3.064,P=0.002);治疗后2组间BUT比较,差异无统计学意义(P>0.05)。(3)SⅠT:试验组治疗后SⅠT长于治疗前,差异有统计学意义(Z=3.833,P=0.000);对照组治疗前后比较,差异无统计学意义(P>0.05)。治疗后,试验组SⅠT长于对照组,差异有统计学意义(Z=14.400,P=0.000)。(4)TMH:2组治疗后TMH均高于治疗前,差异均有统计学意义(Z_(试验组)=3.786,P=0.000,Z_(对照组)=2.093,P=0.036)。治疗后2组间TMH比较,差异无统计学意义(P>0.05)。(5)FL评分:试验组治疗后FL评分低于治疗前,差异有统计学意义(t=-2.179,P=0.042),对照组治疗前后及治疗后2组间FL评分比较,差异均无统计学意义(P>0.05)。(6)临床疗效:试验组总有效率为90.00%,对照组总有效率为65.00%,2组比较,差异无统计学意义(P>0.05)。(7)安全性评价:2组患者受试眼均未出现任何眼部不良反应。结论雷公藤方雾化熏蒸治疗联合0.1%玻璃酸钠滴眼液点眼对干眼症状的改善有积极作用,可作为临床推广使用。
OBJECTIVE To observe the clinical efficacy of Tripterygium formula aerosol inhalation in the treatment of dry eye.METHODS A total of 44 patients(44 eyes)with dry eye who presented at Eye Hospital,China Academy of Chinese Medical Sciences from May 2022 to December 2022 were enrolled and randomly divided into a treatment group(TG)and a control group(CG),with 22 cases(22 eyes)in each group.Finally,20 cases(20 eyes)were included in each group.The treatment group received Tripterygium formula aerosol inhalation combined with 0.1%sodium hyaluronate eye drops,while the control group received placebo aerosol inhalation combined with 0.1%sodium hyaluronate eye drops.Both groups were treated for 28 days.OSDI scores,tear film breakup time(BUT),SchirmerⅠtest(SⅠT),tear meniscus height(TMH),and corneal fluorescein staining(FL)scores were measured before and after treatment in both groups.RESULTS(1)OSDI scores:OSDI scores of both groups after treatment were lower than those before treatment,and the differences were statistically significant(t_(TG)=5.945,t_(CG)=4.559,both P=0.000).There was no statistically significant difference in OSDI scores between the two groups after treatment(P>0.05).(2)BUT:BUT of both groups after treatment was longer than that before treatment,and the differences were statistically significant(Z_(TG)=-3.734,P=0.000;Z_(CG)=-3.064,P=0.002).There was no statistically significant difference in BUT between the two groups after treatment(P>0.05).(3)SⅠT:SⅠT of the treatment group after treatment was longer than that before treatment,and the difference was statistically significant(Z=3.833,P=0.000);There was no statistically significant difference in the control group before and after treatment(P>0.05).After treatment,SⅠT of the treatment group was longer than that of the control group,and the difference was statistically significant(Z=14.400,P=0.000).(4)TMH:TMH of both groups after treatment was higher than that before treatment,and the differences were statistically significant(Z_(TG)=3.786,P=0.000;Z_(CG)=2.093,P=0.036).There was no statistically significant difference in TMH between the two groups after treatment(P>0.05).(5)FL scores:FL scores of the treatment group after treatment were lower than those before treatment,and the difference was statistically significant(t=2.179,P=0.042).There were no statistically significant differences in FL scores in the control group before and after treatment or between the two groups after treatment(P>0.05).(6)Clinical efficacy:The total effective rate was 90.00%in the treatment group and 65.00%in the control group.There was no statistically significant difference between the two groups(P>0.05).(7)Safety evaluation:No ocular adverse reactions occurred in the tested eyes of patients in either group.CONCLUSIONS Tripterygium formula aerosol inhalation combined with 0.1%sodium hyaluronate eye drops has a positive effect on improving dry eye symptoms and can be promoted for clinical use.
作者
李言泷
曹雯媗
吴沂旎
陈亦霞
罗悦
杨剑英
吴宁玲
LI Yanlong;CAO Wenxuan;WU Yini;CHEN Yixia;LUO Yue;YANG Jianying;WU Ningling(Eye Hospital,China Academy of Chinese Medical Sciences,Beijing 100043,China;Shaanxi Provincial Traditional Chinese Medicine Hospital,Xi'an 710003,China;Jiangsu province Zhenjiang City Traditional Chinese Medicine Hospital,Zhenjiang 212003,China)
出处
《中国中医眼科杂志》
2025年第10期922-927,990,共7页
China Journal of Chinese Ophthalmology
基金
中国中医科学院高水平中医医院课题(GSP5-78)。
关键词
干眼
白涩症
雷公藤方
雾化熏蒸
dry eye
Bai Se Zheng
Tripterygium formula
aerosol inhalation
