摘要
为满足神经调控领域对设备灵活性和精确性的更高需求,设计具有可调高精度的多模式经颅电刺激设备。设备以STM32F407ZGT6为核心控制器,搭载FreeRTOS操作系统,采用高精度数字模拟转换芯片AD5676R与增强型Howland恒流源电路构成的电刺激源,结合INA228芯片实现精确的阻抗在线监测。实验结果表明,设备支持单极性和双极性直流、交流、脉冲及噪声输出,在电流输出、频率控制、脉宽调控及阻抗监测方面表现出较高的精度,输出电流在-2~2 mA范围内以1μA步长调节,频率在1~200、200~600和600~800 Hz范围内分别以0.1、0.5和1.0 Hz步长调节,脉宽在0.3~10.0、10~100和100~1000 ms范围内分别以0.1、1.0和2.0 ms步长调节。
A multi-mode transcranial electrical stimulation device with adjustable high precision is designed to meet the higher requirements for device flexibility and precision in the field of neuromodulation.With STM32F407ZGT6 as the core controller,the device is equipped with FreeRTOS operating system,and its electrical stimulation source is composed of a high-precision digital-to-analog converter chip AD5676R and an enhanced Howland constant current source circuit,and it incorporates the INA228 chip to achieve accurate impedance online monitoring.The experimental results show that the device supports unipolar and bipolar direct current,alternating current,pulse and noise outputs,while exhibiting high precision in current output,frequency control,pulse width regulation,and impedance monitoring.The output current is adjustable within the range of-2 to 2 mA at a step size of 1μA;the frequency can be adjusted in the ranges of 1-200,200-600,and 600-800 Hz,with corresponding step sizes of 0.1,0.5 and 1.0 Hz,respectively;and pulse width is adjustable within the ranges of 0.3-10.0,10-100,and 100-1000 ms,with corresponding step sizes of 0.1,1.0 and 2.0 ms,respectively.
作者
王祖榛
王雨欣
宁晓琳
WANG Zuzhen;WANG Yuxin;NING Xiaolin(School of Instrumentation and Optoelectronic Engineering,Beihang University,Beijing 100191,China;Hefei National Laboratory,Hefei 230088,China)
出处
《中国医学物理学杂志》
2025年第9期1212-1220,共9页
Chinese Journal of Medical Physics
基金
科技创新2030“量子通信与量子计算机”重大项目(2021ZD0300503)。
关键词
神经调控
可调高精度
多模式经颅电刺激
电刺激源
阻抗监测
neuromodulation
adjustable high-precision
multimodal transcranial electrical stimulation
electrical stimulation source
impedance monitoring
