摘要
目的探讨三磷酸腺苷辅助硝苯地平治疗对妊娠期高血压性心脏病对产妇血压水平、心功能及妊娠结局的影响。方法选取2021年2月至2023年3月黄石爱康医院收治的328例妊娠期高血压心脏病产妇作为研究对象,按照随机数字表法分为观察组与对照组,每组164例。对照组采用硝苯地平缓释片治疗,观察组在对照组基础上加用三磷酸腺苷二钠注射液。比较两组临床疗效、血压水平[舒张压(diastolic blood pressure,DBP)及收缩压(systolic blood pressure,SBP)]、心功能指标[左心室舒张末期内径(left ventricular end-diastolic dimension,LVEDD)、左心室射血分数(left ventricular ejection fraction,LVEF)、心脏指数(cardiac index,CI)、左心室舒张早期/晚期峰值流速(early diastolic peak velocity/late diastolic peak velocity ratio,E/A)和6 min步行距离(6-minute walk distance,6MWD)]、不良妊娠结局及不良反应发生率。结果观察组治疗总有效率为95.12%,高于对照组的78.05%,差异有统计学意义(P<0.05);治疗后,观察组DBP、SBP低于对照组,LVEDD短于对照组,LVEF、CI、E/A均高于对照组,6MWD长于对照组,差异有统计学意义(P<0.05);观察组不良妊娠结局发生率为6.71%,低于对照组的18.29%,差异有统计学意义(P<0.05);治疗期间,两组不良反应发生率比较差异无统计学意义。结论三磷酸腺苷联合硝苯地平治疗妊娠期高血压性心脏病临床疗效显著,可降低产妇血压水平,改善心功能,减少不良妊娠结局的发生,且安全性较高。
Objective To investigate the effects of adenosine triphosphate assisted nifedipine treatment on blood pressure levels,cardiac function,and pregnancy outcomes in pregnant women with hypertensive heart disease.Methods A total of 328 pregnant women with gestational hypertension and heart disease admitted to Huangshi Aikang Hospital from February 2021 to March 2023 were selected as the research subjects,and they were divided into the observation group and the control group according to the random number table method,with 164 cases in each group.The control group was treated with nifedipine sustained-release tablets,while the observation group was added with disodium adenosine triphosphate injection on the basis of the control group.The clinical efficacy,blood pressure levels(diastolic blood pressure[DBP]and systolic blood pressure[SBP]),cardiac function indicators(left ventricular end-diastolic diameter[LVEDD],left ventricular ejection fraction[LVEF],cardiac index[CI],early diastolic peak velocity/late diastolic peak velocity ratio[E/A]and 6-minute walk distance[6MWD],the incidence of adverse pregnancy outcomes and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 95.12%,which was higher than 78.05%in the control group,and the difference was statistically significant(P<0.05).After treatment,the DBP and SBP in the observation group were lower than those in the control group,LVEDD was shorter than that in the control group,LVEF,CI,E/A were higher than those in the control group,and 6MWD was longer than that in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse pregnancy outcomes in the observation group was 6.71%,which was lower than the 18.29%in the control group,and the difference was statistically significant(P<0.05).During the treatment period,there was no statistically significant difference in the incidence of adverse reactions between the two groups.Conclusion Adenosine triphosphate combined with nifedipine has remarkable clinical effect in the treatment of hypertensive heart disease during pregnancy,it can lower the blood pressure level of parturients,improve cardiac function,reduce the occurrence of adverse pregnancy outcomes,and has relatively high safety.
作者
邹璐
胡道信
徐艳芳
ZOU Lu;HU Daoxin;XU Yanfang(Department of Obstetrics,Huangshi Aikang Hospital,Huangshi,Hubei,435000,China)
出处
《当代医学》
2025年第7期34-37,共4页
Contemporary Medicine
关键词
妊娠期高血压性心脏病
三磷酸腺苷
硝苯地平
血压
心功能
妊娠结局
Hypertensive heart disease during pregnancy
Adenosine triphosphate
Nifedipine
Blood pressure
Heart function
Pregnancy outcome
