摘要
目的:分析多囊卵巢综合征(PCOS)伴不孕患者体外受精-胚胎移植(IVF-ET)后发生妊娠丢失的影响因素。方法:回顾性分析2021年1月至2023年1月于该院行IVF-ET治疗的128例PCOS伴不孕患者的临床资料。根据是否发生妊娠丢失分为丢失组(n=24)与未丢失组(n=104)。采用Logistic回归分析PCOS伴不孕患者IVF-ET后发生妊娠丢失的影响因素。结果:128例PCOS伴不孕患者IVFET后发生妊娠丢失24例,占18.75%,未发生妊娠丢失104例,占81.25%。单因素分析结果显示,两组年龄、不孕年限、获卵数目、可利用胚胎数、优质胚胎数、合并高血压、合并糖尿病占比和雌二醇、卵泡刺激素、黄体生成素水平等比较,差异均无统计学意义(P<0.05);丢失组孕前体质量指数(BMI)≥22.75 kg/m^(2)、睾酮≥0.97 ng/L、胰岛素生长因子-1(IGF-1)<167.57 ng/mL、孕酮<9.61 ng/mL、维生素D<18.55 ng/mL等占比均高于未丢失组,差异有统计学意义(P<0.05);Logistic回归分析结果显示,孕前BMI≥22.75 kg/m^(2)、睾酮≥0.97 ng/L、IGF-1<167.57 ng/mL、孕酮<9.61 ng/mL、维生素D<18.55 ng/mL等均为影响PCOS伴不孕患者IVF-ET后发生妊娠丢失的危险因素(OR>1,P<0.05)。结论:孕前BMI≥22.75 kg/m^(2)、睾酮≥0.97 ng/L、IGF-1<167.57 ng/mL、孕酮<9.61 ng/mL、维生素D<18.55 ng/mL等均为影响PCOS伴不孕患者IVF-ET后发生妊娠丢失的危险因素。
Objective:To analyze influencing factors of pregnancy loss after in vitro fertilization-embryo transfer(IVF-ET)in infertile patients with polycystic ovary syndrome(PCOS).Methods:The clinical data of 128 PCOS patients with infertility who underwent IVF-ET treatment in this hospital from January 2021 to January 2023 were retrospectively analyzed.According to whether pregnancy loss occurred,they were divided into loss group(n=24)and non-loss group(n=104).Logistic regression was used to analyze the influencing factors of pregnancy loss after IVF-ET in the PCOS patients with infertility.Results:There were 24 cases of pregnancy loss in the 128 PCOS patients with infertility after IVF-ET,accounting for 18.75%,and 104 cases of pregnancy loss did not occur,accounting for 81.25%.The univariate analysis showed that there were no significant differences in the proportions of age,infertility years,number of retrieved oocytes,number of available embryos,number of high-quality embryos,combined hypertension,combined diabetes,and levels of estradiol,follicle stimulating hormone and luteinizing hormone between the two groups(P<0.05).The proportions of the cases with pre-pregnancy body mass index(BMI)≥22.75 kg/m^(2),testosterone≥0.97 ng/L,insulin growth factor-1(IGF-1)<167.57 ng/mL,progesterone<9.61 ng/mL,and vitamin D<18.55 ng/mL in the loss group were higher than those in the non-loss group,and the differences were statistically significant(P<0.05).Logistic regression analysis showed that pre-pregnancy BMI≥22.75 kg/m^(2),testosterone≥0.97 ng/L,IGF-1<167.57 ng/mL,progesterone<9.61 ng/mL,and vitamin D<18.55 ng/mL were all risk factors for pregnancy loss after IVF-ET in the PCOS patients with infertility(OR>1,P<0.05).Conclusions:Pre-pregnancy BMI≥22.75 kg/m^(2),testosterone≥0.97 ng/L,IGF-1<167.57 ng/mL,progesterone<9.61 ng/mL,and vitamin D<18.55 ng/mL are the risk factors for pregnancy loss after IVF-ET in the PCOS patients with infertility.
作者
杨晓亮
邢冠琳
何钰辉
柳胜贤
宋瑞芳
YANG Xiaoliang;XING Guanlin;HE Yuhui;LIU Shengxian;SONG Ruifang(Department of Reproductive Medicine of Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang 471000 Henan,China)
出处
《中国民康医学》
2025年第18期24-27,共4页
Medical Journal of Chinese People’s Health
关键词
多囊卵巢综合征
不孕
体外受精-胚胎移植
妊娠丢失
Polycystic ovary syndrome
Infertility
In vitro fertilization-embryo transfer
Pregnancy loss
