摘要
目的探讨阿尔茨海默病(alzheimer disease,AD)患者不同病程进展阶段认知神经网络的变化特点,为AD发病机制及早期诊疗提供电生理依据。方法前瞻性选取2018年9月至2022年6月天津医科大学总医院神经内科门诊收治的患者84例,根据病情程度分为AD组42例和轻度认知功能障碍(mild cognitive impairment,MCI)组42例,同期选择体检的健康者42例作为健康对照(healthy control,HC)组,采用Matlab软件分析后静息态脑电数据并应用自编程序进行相干性分析,采用单因素方差分析三组六个频段半球间及半球内相干值。结果AD组脑电相干值前头部(额区+前颞区)相关电极对低于HC组(P<0.05),以Alpha、Beta优势频段为主,优势半球为主,后头部(颞区为主)相关电极对高于HC组(P<0.05),以Gamma频段为主。双侧半球间除Alpha频段外的所有频段,AD组在多数电极对相干值高于HC组,在Gamma频段最为广泛。MCI组仅表现出右侧Alpha频段枕后颞区(O2-T6)电极对相干值高于HC组(P<0.05)。AD组两半球内除Gamma频段外在前头部额区相关电极对相干值低于MCI组(P<0.05),以Alpha、Beta频段为主。半球间相干值结果显示,AD组在全频段及Gamma频段绝大部分电极对高于MCI组(P<0.05)。结论脑电相干性可为AD发病机制和早期诊断提供电生理依据。
Objective To explore the changes in cognitive neural networks in AD patients at different stages of disease progression to provide electrophysiological basis for the pathogenesis and early diagnosis and treatment of AD.Methods A total of 84 patients admitted to Department of Neurology of General Hospital of Tianjin Medical University from September 2018 to June 2022 were prospectively recruited,and divided into AD patients group(42 cases)and MCI group(42 cases)according to their disease severity.Another 42 healthy individuals who taking physical examination during the same period were subjected and served as HC group.Post-resting EEG data were analyzed with Matlab software,and coherence analysis was performed by selfprogrammed program.Univariate analysis of variance was used to compare the interhemispheric and intra-hemispheric coherence values of six frequency bands in the three groups.Results The cohe-rence values of the related electrode pairs in the anterior head(frontal region+anterior temporal region)were significantly lower in the AD group than in the HC group(P<0.05),with the Alpha and Beta dominant bands and dominant hemispheres dominant,while the values of related electrode pairs in the posterior head(temporal region)were obviously higher in the AD group than the HC group(P<0.05),with the Gamma band dominant.In all the frequency bands except the Alpha band,the AD group had higher coherence values in most of the electrode pairs than the HC group,and the Gamma band was the most extensive.In the MCI group,only the coherence value of the electrodes in the occipito-posterior temporal region(O2-T6)in the right Alpha band was higher than that in the HC group(P<0.05).Except Gamma band,the coherence value of therelated electrode pairs in the frontal region was notably lower in the AD group than the MCIgroup(P<0.05),and the Alpha and Beta bands were dominant.The results of interhemisphericcohe-rence showed that most of the electrode pairs in the AD group had higher coherence valuesthan the MCI group in all the frequency bands and the Gamma band(P<0.05).Conclusion EEGcoherence can provide electrophysiological basis for the pathogenesis and early diagnosis of AD.
作者
徐梅松
李伟海
陶华英
Xu Meisong;Li Weihai;Tao Huaying(Department of Neurology,Tianjin Fifth Central Hospital,Tianjin 300450,China)
出处
《中华老年心脑血管病杂志》
北大核心
2025年第10期1399-1404,共6页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词
阿尔茨海默病
认知功能障碍
脑电描记术
Alzheimer disease
cognitive dysfunction
electroencephalography
