摘要
目的观察同型半胱氨酸(homocysteine,Hcy)、高敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)及睾酮水平与老年男性脑动脉粥样硬化(atherosclerosis,AS)患者的关联性。方法纳入2020年5月至2022年5月邢台市中心医院神经内科收治的老年男性脑AS患者118例(AS组),AS组又根据斑块性质分为不稳定性斑块组37例和稳定性斑块组81例。同期选取来我院体检的老年男性健康体检者118例(非AS组)。测定各组血清Hcy、hs-CRP、睾酮水平,分析Hcy、hs-CRP、睾酮水平与脑AS的关系。结果AS组高脂血症、Hcy、hs-CRP水平明显高于非AS组,睾酮水平明显低于非AS组(P<0.01)。Pearson相关性分析显示,Hcy、hs-CRP水平与脑动脉狭窄程度呈正相关,睾酮水平与脑动脉狭窄程度呈负相关(P<0.01)。多因素logistic回归分析显示,高脂血症(OR=4.651,95%CI:1.790~12.080,P=0.002)、Hcy(OR=1.592,95%CI:1.112~2.279,P=0.011)、hs-CRP(OR=2.951,95%CI:1.412~6.165,P=0.004)是老年男性发生脑AS的危险因素,睾酮是老年男性发生脑AS的保护因素(OR=0.661,95%CI0.450~0.971,P=0.035)。不稳定性斑块组Hcy、hs-CRP水平明显高于稳定性斑块组,睾酮水平明显低于稳定性斑块组,差异有统计学意义(P<0.05,P<0.01)。ROC曲线分析显示,Hcy、hs-CRP、睾酮水平评估老年男性脑AS患者斑块稳定性的AUC分别为0.806、0.795、0.712。结论Hcy、hs-CRP、睾酮水平异常与老年男性脑AS发生风险相关,且Hcy、hs-CRP、睾酮水平对斑块的稳定性有一定的预测价值。
Objective To investigate the associations between homocysteine(Hcy),high sensitivity C-reactive protein(hs-CRP)and testosterone levels and elderly male cerebral atherosclerosis(AS).Methods A total of 118 elderly male patients with cerebral AS admitted to our department from May 2020 to May 2022 were recruited and served as AS group.The group were further divided into an unstable plaque subgroup(37 cases)and a stable plaque subgroup(81 cases)according to the plaque property.Another 118 healthy elderly males who taking health checkup in our hospital during the same period were subjected and served as the non-AS group.The levels of serum Hcy,hs-CRP and testosterone were measured in all participants.The relationship between Hcy,hs-CRP and testosterone levels and cerebral AS was analyzed.Results The AS group had significantly larger proportion of hyperlipidemia and higher levels of Hcy and hs-CRP,but lower testosterone level when compared with the non-AS group(P<0.o1).Multivariate logistic regression analysis identified hyperlipidemia(OR=4.651,95%CI:1.790-12.080,P=0.002),Hcy(OR=1.592,95%CI:1.112-2.279,P=0.011)and hs-CRP(OR=2.951,95%CI:1.412-6.165,P=0.004)were risk factors,while testosterone was a protective factor(OR=0.661,95%CI:0.450-0.971,P=0.035)for occurrence of cerebral AS in elderly males.The levels of Hcy and hs-CRP were notably higher,and that of testosterone was remarkably lower in the unstable plaque subgroup than the stable plaque subgroup(P<0.05,P<0.01).ROC curve analysis indicated that the AUC value of Hcy,hs-CRP and testosterone in evaluating plaque stability in elderly male patients with cerebral AS was 0.806,0.795 and 0.712,respectively.Conclusion The abnormal levels of Hcy,hs-CRP and testosterone are related to the risk of cerebral AS in elderly males,and their levels have certain predictive value in predicting the plaque stability.
作者
张晓林
钱丽花
庞学波
王美蓉
孔咏梅
Zhang Xiaolin;Qian Lihua;Pang Xuebo;Wang Meirong;Kong Yongmei(Department of Neurology,Xingtai Central Hospital,Xingtai 054000,Hebei Province,China)
出处
《中华老年心脑血管病杂志》
北大核心
2025年第10期1363-1366,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
邢台市重点研发计划自筹项目(2020ZC185)。
关键词
颅内动脉硬化
高半胱氨酸
C反应蛋白质
睾酮
intracranial arteriosclerosis
homocysteine
C-reactive protein
testosterone
