摘要
肝细胞癌(HCC)是全球范围内导致癌症相关死亡的主要原因之一,HCC是典型的免疫原性肿瘤,其复杂的免疫微环境在肿瘤的发生和发展中起着关键作用。近年来,免疫抑制细胞和循环肿瘤细胞(CTC)之间的相互网络交互作用促进HCC免疫逃逸和转移引起了广泛关注。CTC如何逃避免疫监视和被免疫细胞清除仍不清楚。本文聚焦循环肿瘤细胞与免疫抑制细胞的调控网络及免疫逃逸的关键通路,引入外泌体调控和单细胞多组学技术解析细胞互作机制,系统阐述靶向PD-L1、CCL5等通路的临床转化挑战,并提出人工智能驱动的个体化治疗前景。
Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related mortality worldwide.As a typical immunogenic tumor,HCC has a complex immune microenvironment that plays a crucial role in its initiation and progression.In recent years,the interactive network between immunosuppressive cells and circulating tumor cells(CTCs)has drawn increasing attention for its role in promoting HCC immune evasion and metastasis.However,how CTCs escape immune surveillance and clearance by immune cells remains unclear.This article focuses on the regulatory networks between CTCs and immunosuppressive cells as well as the key pathways of immune evasion,introduces exosome-mediated regulation and single-cell multi-omics technologies to dissect mechanisms of cellular interactions,systematically discusses the clinical translational challenges of targeting pathways such as PD-L1 and CCL5,and proposes future prospects for personalized therapy driven by artificial intelligence.
作者
方兴保
李月宏
蔡艳
FANG Xingbao;LI Yuehong;CAI Yan(Department of Hepatobiliary and Pancreatic Surgery,the Affiliated Qujing Hospital of Kunming Medical University(Qujing Central Hospital),Qujing,Yunnan 655000,China;Department of Pathology,Qujing Health Medical College,Qujing,Yunnan 655000,China)
出处
《中国普通外科杂志》
北大核心
2025年第7期1523-1531,共9页
China Journal of General Surgery
基金
云南省基础研究计划昆医联合专项重点基金资助项目(202301AY070001-019,202401AY070001-260)
云南省教育厅科学研究基金资助项目(2025J1662)。
关键词
癌
肝细胞
肿瘤微环境
免疫检查点抑制剂
肿瘤细胞
循环
肿瘤免疫逃逸
综述
Carcinoma,Hepatocellular
Tumor Microenvironment
Immune Checkpoint Inhibitors
Neoplastic Cells,Circulating
Tumor Immune Escape
Review
