摘要
人乳头瘤病毒(human papillomavirus,HPV)42最初从良性外阴乳头状瘤中分离出来,常导致尖锐湿疣等良性病变。长期以来,HPV42被认为是一种非致癌或低致癌风险的HPV基因亚型,然而,最近的研究已经证实HPV42不仅是指/趾乳头状腺癌的致癌驱动因子,还与子宫颈和肛门部位高级别鳞状上皮内病变相关,且频繁感染口咽部。HPV42呈现出类似高危型HPV的致癌分子特征,引发对其被归类为“低风险”致癌类型的质疑。本文综述了HPV42感染相关性皮肤肿瘤和生殖器病变的关联机制、临床病理特征和流行病学特点的研究进展。
Human papillomavirus 42(HPV42)is originally isolated from benign vulvar papillomas and often lead to benign lesions such as anogenital warts.For a long time,HPV42 is considered as a non-oncogenic or low-risk(LR)HPV genotype,recent studies have shown that HPV42 can drives the digital papillary adenocarcinoma(DPA),and is also associated with high-grade squamous intraepithelial lesion(HSIL)in the cervical and anal regions,as well as frequent infections in the oropharyngeal region.The molecular hallmarks of oncogenic that exhibited by HPV 42 are similar to those of high-risk(HR)HPV gentypes,raising questions about its classification as an“LR-HPV”.This study provides a comprehensive review of the research progress on the mechanisms,clinical-pathological features,and epidemiological characteristics of HPV42 infection-associated skin tumors and genital lesions.
作者
赵姝姝
孙万里
沈蓁
马春强
刘蒙蒙
ZHAO Shushu;SUN Wanli;SHEN Zhen;MA Chunqiang;LIU Mengmeng(Department of Oncology,Affiliated Hospital of Shandong Second Medical University,Weifang 261031,China;Department of Clinical Laboratory,Affiliated Hospital of Shandong Second Medical University,Weifang 261031,China)
出处
《中国皮肤性病学杂志》
北大核心
2025年第9期1047-1052,共6页
The Chinese Journal of Dermatovenereology
基金
山东省自然科学基金青年项目(ZR2023QH061)
2023年度潍坊市卫健委科研项目计划(WFWSJK-2023-062)
潍坊医学院附属医院博士科研启动基金资助项目(2021BKQD4)。
关键词
人乳头瘤病毒42型
指/趾乳头状腺癌
肛门-生殖器癌
脂溢性角化病样病变
高级别鳞状上皮内病变
流行率
Human papillomavirus 42(HPV42)
Digital papillary adenocarcinoma(DPA)
Anogenital carcinoma
Seborrheic keratosis-like lesion
High-grade squamous intraepithelial lesion(HSIL)
Prevalence rate
