摘要
高尿酸血症(Hyperuricemia,HUA)是一种代谢性疾病,除了可以引起痛风外,还是肾脏、内分泌代谢、心脑血管等系统疾病的独立危险因素。近年来,随着果糖摄入量的显著上升,尤其是通过软饮料的广泛消费,众多流行病学研究及临床观察均指出,果糖摄入与HUA的发生和发展之间存在着密切的联系。在代谢层面,果糖在肝脏的代谢过程中能够生成尿酸的前体物质——嘌呤;同时,果糖在肾脏中干预尿酸排泄机制,进一步引起血尿酸水平的上升。此外,果糖可能通过对胰岛素敏感性的影响以及增加肥胖的风险,间接影响尿酸的代谢过程。尽管现有研究已经揭示了果糖与HUA之间的关联性,然而其具体的作用机制尚未得到明确。该综述综合分析果糖对HUA的影响及作用机制,以期加深人们对果糖与HUA关系的理解,为HUA的饮食干预策略提供理论支持。
Hyperuricemia(HUA),a metabolic disorder,is not only associated with gout but also represents an independent risk factor for numerous systemic diseases,such as kidney,endocrine,metabolic,and cardiovascular disorders.Recently,numerous epidemiological studies and clinical observations have indicated that the considerable increase in fructose consumption,particularly through the widespread consumption of soft drinks,is closely linked to the occurrence and progression of HUA.At the metabolic level,fructose can generate urate precursors in the liver during metabolism,and it interferes with the uric acid excretion process in the kidneys,leading to an increase in serum uric acid levels.Furthermore,fructose may indirectly affect urate metabolism through its impact on insulin sensitivity and the risk of obesity.Although existing research has already revealed the association between fructose and HUA,the specific mechanisms remain unclear.This review investigates the impact of fructose on HUA and its underlying mechanisms,aiming to deepen our understanding of the relationship between fructose and HUA and provide theoretical support for dietary intervention strategies for HUA.
作者
程梅芳
王洋
闫思雅
李阁
刘梦扬
王丹
CHENG Meifang;WANG Yang;YAN Siya;LI Ge;LIU Mengyang;WANG Dan(Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《现代食品科技》
北大核心
2025年第8期338-348,共11页
Modern Food Science and Technology
基金
国家自然科学基金资助项目(82304870)。
关键词
果糖
软饮料
高尿酸血症
fructose
soft drinks
hyperuricemia
