摘要
目的:对比多囊卵巢综合征(PCOS)患者采用黄体期长方案与拮抗剂方案控制性超促排卵的体外受精(IVF)助孕结局。方法:采取回顾性研究,将2022年8月—2024年5月在贺州市人民医院接受控制性超促排卵IVF助孕的107例PCOS患者作为研究对象,根据治疗方案分组,其中黄体期长方案组(56例)接受黄体期长方案治疗,拮抗剂方案组(51例)接受拮抗剂方案治疗。比较两组促排卵相关指标[促性腺激素(Gn)使用天数、Gn用量、双原核受精率、优胚率、新鲜移植周期取消率]及妊娠结局。结果:拮抗剂方案组Gn使用天数、Gn用量均少于黄体期长方案组(P<0.001),优胚率高于黄体期长方案组(P<0.001)。两组获卵数、双原核受精率、新鲜移植周期取消率比较,无统计学差异(P>0.05)。两组临床妊娠率比较,无统计学差异(P=0.131)。两组均未发生早期流产。结论:拮抗剂方案在PCOS患者IVF助孕中的应用效果优于黄体期长方案,可缩短Gn用药时间、降低用药量,提高优胚率,对临床妊娠率暂无明显影响。
Objective:To compare in vitro fertilization(IVF)-assisted pregnancy outcomes in patients with polycystic ovary syndrome(PCOS)after controlled ovarian hyperstimulation with luteal phase long protocol and antagonist protocol.Methods:A retrospective study was conducted and a total of 107 PCOS patients who received ovulation induction IVF-assisted pregnancy at the People's Hospital of Hezhou from August 2022 to May 2024 were selected as the study subjects.The patients were divided into groups based on treatment regimens.The luteal phase long protocol group(56 patients)received the luteal phase long protocol treatment,and the antagonist protocol group(51 patients)received the antagonist protocol treatment.The ovulation inductionrelated indicators[gonadotropins(Gn)use days,Gn dosage,two pronuclei fertilization rate,high-quality embryo rate,and fresh cycle embryo transfer cancellation rate]and pregnancy outcomes were compared between the two groups.Results:The Gn use days and Gn dosage in the antagonist protocol group were less than those in the luteal phase long protocol group(P<0.001),and the high-quality embryo rate in the antagonist protocol group was higher than that in the luteal phase long protocol group(P<0.001).There were no statistically significant differences in the number of oocytes retrieved,two pronuclei fertilization rate and fresh transfer cycle cancellation rate between the two groups(P>0.05).There was no statistically significant difference in clinical pregnancy rate between the two groups(P=0.131).No early abortion occurred in either group.Conclusion:The application effect of antagonist protocol is better than that of luteal phase long protocol in IVF-assisted pregnancy of PCOS patients,the former can shorten the duration of Gn use,reduce the drug consumption,increase high-quality embryo rate,with no significant impact on clinical pregnancy rates at present.
作者
孔知音
黎翠凤
陈周详
廖观德
吴婷姣
Kong Zhiyin;Li Cuifeng;Chen Zhouxiang;Liao Guande;Wu Tingjiao(The People's Hospital of Hezhou,Hezhou 542899,Guangxi Zhuang Autonomous Region,China)
出处
《中外医药研究》
2025年第21期32-34,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
基金
贺州市科学研究与技术开发计划项目(编号:贺科技2023053)。
关键词
多囊卵巢综合征
体外受精
黄体期长方案
拮抗剂方案
Polycystic ovary syndrome
In vitro fertilization
Luteal phase long protocol
Antagonist protocol
