摘要
The endoplasmic reticulum(ER)is an important targeting organelle for metal-based immunogenic cell death(ICD)inducers.Metal complexes can induce ER stress by causing protein misfolding,which can be reflected by alternations in micro-environmental parameters,including viscosity.We present here a theranostic Re(I)complex(Re1)that shows viscosity-dependent emission intensity and lifetime.Re1 can trigger immunogenic cell death(ICD)in MDA-MB-231 cells by localizing in the ER and causing ER stress.We demonstrate that Re1 can simultaneously induce and monitor the gradual increase in the ER viscosity quantitatively.
基金
supported by the National Natural Science Foundation of China(Nos.22022707 and 22177142)
the Fundamental Research Funds for the Central Universities。
