摘要
随着老龄化社会的到来,膝骨关节炎(KOA)发病率逐渐上升,成为全球范围内亟待解决的健康问题。近年来,自体富血小板血浆(PRP)和同种异体PRP因其在促进软骨修复和减少关节疼痛方面的潜力而受到广泛关注。多项研究证明自体PRP治疗KOA的安全性和有效性,但其疗效因PRP成分缺乏标准化而受到质疑。同种异体PRP,尤其是脐血来源PRP,具有明显的特点和特殊群体优势,尽管其研究历史相对较短,但它在KOA治疗中也得到了有效的结论。然而,两者在效果、机制及应用前景上的比较尚缺乏系统性综述,且各自的优势和局限性有待深入探讨。本文旨在通过系统综述现有文献,探讨自体PRP与同种异体PRP在KOA治疗中的效果,解析其作用机制,并展望未来研究方向,以期为临床实践提供参考。
With the advent of an aging society,the incidence of knee osteoarthritis(KOA)is gradually increasing,becoming an urgent health problem to be solved worldwide.In recent years,autologous platelet-rich plasma(PRP)and allogeneic PRP have gained significant attention for their potential in promoting cartilage repair and reducing joint pain.Several studies have demonstrated the safety and efficacy of autologous PRP in the treatment of KOA,but its efficacy has been questioned due to the lack of standardization of PRP components.Allogeneic PRP,especially cord blood-derived PRP,has distinct characteristics and special population advantages,and despite its relatively short research history,it has also been effectively concluded in the treatment of KOA.However,there is still a lack of a systematic review of the effects,mechanisms and application prospects of the two methods,and their advantages and limitations need to be explored in depth.This article aims to systematically review the existing literature,explore the effects of autologous PRP and allogeneic PRP in the treatment of KOA,analyze their mechanisms,and look forward to future research directions,in order to provide reference for clinical practice.
作者
陈曦
孟萍萍
Chen Xi;Meng Pingping(Department of Rehabilitation Medicine,Liaocheng People’s Hospital,Liaocheng,Shandong 252000,China;Department of Rehabilitation Medicine,Affiliated Hospital of Qingdao University,Qingdao,Shandong 266000,China)
出处
《中国康复》
2025年第9期566-571,共6页
Chinese Journal of Rehabilitation
关键词
膝骨关节炎
自体PRP
同种异体PRP
软骨修复
关节治疗
knee osteoarthritis
autologous platelet-rich plasma
allogeneic platelet-rich plasma
cartilage repair
joint therapy
