摘要
目的 探讨恩他卡朋双多巴联合艾地苯醌治疗帕金森病(PD)的临床效果。方法 选取2021年3月至2023年12月安阳市人民医院收治的60例PD患者,随机数字表法分为联合组(30例,给予恩他卡朋双多巴联合艾地苯醌)和对照组(30例,给予艾地苯醌),治疗3个月。比较两组治疗效果、血清脑源性神经营养因子(BDNF)、神经生长因子(NGF)、胰岛素样生长因子(IGF)-1水平、帕金森病自主神经症状量表(SCOPA-AUT)、帕金森病生活质量评分量表(PDQ-39)、匹兹堡睡眠质量指数(PSQI)评分及不良反应。结果 联合组治疗总有效率(93.33%)较对照组(73.33%)升高(P<0.05);治疗3个月后,联合组SCOPA-AUT、PSQI、PDQ-39评分低于对照组,血清NGF、BDNF、IGF-1水平均高于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P >0.05)。结论 恩他卡朋双多巴联合艾地苯醌治疗能有效改善PD临床症状,提升自主神经功能,调节血清中神经营养因子水平,且安全性较高。
Objective To investigate the clinical efficacy of entacapone levodopa and carbidopa combined with idebenone in the treatment of Parkinson’s disease(PD).Methods Sixty patients with PD admitted to Anyang People’s Hospital from March 2021 to December 2023 were selected and divided into combined group(30 cases,accepted entacapone levodopa and carbidopa combined with idebenone)and control group(30 cases,accepted idebenone)for 3 months according to the random number table method.The treatment efficacy,the serum brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF),insulin-like growth factor(IGF)-1 levels,the scores of scales for outcomes in Parkinson’s disease-autonomic(SCOPA-AUT),Parkinson’s disease questionnaire-39(PDQ-39),Pittsburgh sleep quality index(PSQI)and adverse reactions were compared between two groups.Results The total effective rate of treatment in the combined group(93.33%)was higher than that in the control group(73.33%)(P<0.05).After 3 months of treatment,SCOPA-AUT,PSQI and PDQ-39 scores in the combined group were lower than those in the control group,and serum NGF,BDNF and IGF-1 levels were higher than those in the control group(P<0.05).Adverse reaction rates showed no difference between two groups(P>0.05).Conclusion Entacapone levodopa and carbidopa combined with idebenone can effectively improve the clinical symptoms of PD,improve autonomic nerve function,regulate the level of neurotrophic factors in serum,and has high safety.
作者
于洁
李海燕
王祎纯
黄耀萱
韩爽
YU Jie;LI Haiyan;WANG Yichun;HUANG Yaoxuan;HAN Shuang(Department of Neurology,Anyang People’s Hospital,Anyang 455000,China)
出处
《河南医学研究》
2025年第18期3412-3415,共4页
Henan Medical Research
基金
河南省医学科技攻关计划联合共建项目(LHGJ20240521)。
关键词
帕金森病
恩他卡朋双多巴
艾地苯醌
神经功能
疗效
Parkinson’s disease
entacapone levodopa and carbidopa
idebenone
neurological function
curative effect
